Tubulocystic Renal Cell Carcinoma
Tubulocystic carcinoma is an uncommon multicystic renal cell tumor.
The tumor comprises less than 1% of all renal carcinomas.
Tubulocystic carcinoma occurs most commonly in the fifth and sixth decades of life.
There is a male predominance.
There is no site predilection.
Radical nephrectomy is generally recommended, but partial nephrectomy may be performed for small tumors located in the superficial renal cortex.
They usually display an indolent behavior with a few cases with metastasis or recurrence.
The tumors are solitary well-circumscribed multicystic renal mass. They are frequently 4 cm or less and composed of multiple small- to intermediate-sized cysts and have a white and sponge-like cut surface.
Neoplastic cells stain for CK7, 34βE12, AMACR, and CD10.
Tubulocystic carcinoma shows gains of chromosomes 17 and loss of the Y chromosome and chromosome 9 (Sarungbam et al. 2019).
The differential diagnosis includes cystic nephroma (immunohistochemical expression of estrogen and progesterone receptor), hereditary leiomyomatosis and renal cell carcinoma-associated renal cell carcinoma (FH loss), and papillary renal cell carcinoma (papillary architecture).