Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken


  • Maria Rosaria RaspolliniEmail author
  • Antonio Lopez-Beltran
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4807-1



Lesion with endocervical-type mucinous epithelium involving the wall of the urinary bladder.

Clinical Features

  • Incidence


  • Age

    Reproductive age.

  • Sex


  • Site

    Bladder posterior wall or posterior dome.

  • Treatment

    Partial cystectomy may be required.


2–5 cm mass of the bladder wall.


Benign appearing or slightly atypical endocervical-type mucinous glands irregularly disposed in an extensively involved bladder wall. Some endocervical-type glands are cystically dilated. Peri-glandular fibrosis and edema may be present in some cases, and extravasated mucin may be in association with ruptured glands. The glands in endocervicosis are typically lined by cuboidal or flattened cells with eosinophilic cytoplasm (Fig. 1). One case showed extravesical pelvic soft tissue involvement (Young and Clement 1992).
Fig. 1

Endocervicosis: endocervical-type epithelium


Immunohistochemically, the endocervicosis is positive for cytokeratin (CK) 7, estrogen receptor, CKAE1/AE3, CAM5.2, and CA19-9, and negative for CK20, CDX2, MUC5AC, and progesterone receptor.

Differential Diagnosis

The differential diagnosis of bladder endocervicosis includes bladder adenocarcinoma and glandular cystitis. Both pathologic features and the immunohistochemical profile can be of assitance. Rarely, primary adenocarcinoma may arise in endocervicosis (Nakaguro et al. 2016).

References and Further Reading

  1. Nakaguro, M., Tsuzuki, T., Shimada, S., et al. (2016). Adenocarcinoma arising in urinary bladder endocervicosis. Pathology International, 66, 108–113.CrossRefGoogle Scholar
  2. Young, R. H., & Clement, P. B. (1992). Endocervicosis of the urinary bladder. A report of six cases of a benign mullerian lesion that may mimic adenocarcinoma. The American Journal of Surgical Pathology, 216, 533–542.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Maria Rosaria Raspollini
    • 1
    Email author
  • Antonio Lopez-Beltran
    • 2
    • 3
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain