Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Mucoepidermoid Carcinoma of the Breast

  • Maria P. Foschini
  • Luca Morandi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4766-1

Definition

Mucoepidermoid carcinoma (MEC) of the breast is a tumor composed of mucous-secreting intermediate and epidermoid cells. It can present a great variety of architectural patterns, ranging from cystic to solid. Its features are similar MEC arising in the major and minor salivary glands (Foschini et al. 2017; Foschini and Krausz 2010).

Clinical Features

  • Incidence

    Breast MEC is an extremely rare type of tumor. Its incidence is not exactly known, as only single case or small series are reported (Basburg 2011; Foschini 2017).

  • Age

    MEC affects mainly adult patients, aged from 29 to 80 years.

  • Sex

    At present breast MEC has been described in female patients only.

  • Site

    MEC can arise in all the breast quadrants. When it affects the retro-areolar region, it can present with nipple discharge.

  • Treatment

    Radical surgical resection is the treatment of choice. Axillary lymph node dissection and chemotherapy have been added in high-grade MEC.

  • Outcome

    Outcome mainly depends on MEC grading. MEC,...

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References

  1. Basbug, M., Akbulut, S., Arikanoglu, Z., Sogutcu, N., Firat, U., & Kucukoner, M. (2011). Mucoepidermoid carcinoma in a breast affected by burn scars: Comprehensive literature review and case report. Breast Care (Basel), 6(4), 293–297.CrossRefGoogle Scholar
  2. Camelo-Piragua, S. I., Habib, C., Kanumuri, P., Lago, C. E., Mason, H. S., & Otis, C. N. (2009). Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: A case report with molecular analysis and review of the literature. Human Pathology, 40(6), 887–892.CrossRefPubMedGoogle Scholar
  3. Di Tommaso, L., Foschini, M. P., Ragazzini, T., Magrini, E., Fornelli, A., Ellis, I. O., & Eusebi, V. (2004). Mucoepidermoid carcinoma of the breast. Virchows Archives, 444(1), 13–19.CrossRefGoogle Scholar
  4. Foschini, M. P., & Krausz, T. (2010). Salivary gland-type tumors of the breast: A spectrum of benign and malignant tumors including “triple negative carcinomas” of low malignant potential. Seminar in Diagnostic Pathology, 27(1), 77–90.CrossRefGoogle Scholar
  5. Foschini, M. P., Morandi, L., Asioli, S., Giove, G., Corradini, A. G., & Eusebi, V. (2017). The morphological spectrum of salivary gland type tumours of the breast. Pathology, 49(2), 215–227.CrossRefPubMedGoogle Scholar
  6. Tjalma, W. A., Verslegers, I. O., De Loecker, P. A., & Van Marck, E. A. (2002). Low and high grade mucoepidermoid carcinomas of the breast. European Journal of Gynaecological Oncology, 23(5), 423–425.PubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Biomedical and Neuromotor SciencesUniversity of Bologna, Unit of Anatomic Pathology at Bellaria HospitalBolognaItaly