Definition
Solid papillary carcinoma (SPC) is described in the 2012 WHO classification within the group of the intraductal papillary lesions and is defined as a variant of papillary carcinoma characterized by multiple solid nodules of neoplastic cells arranged around multiple fibrovascular spaces. Despite the lack of the external myoepithelial layer, these lesions are currently considered as noninvasive (Lakhani et al. 2012). However, cases of true invasive SPC exist.
Clinical Features
Incidence
SPC is a rare entity, accounting for 1ā2% of breast carcinomas (BCs) (Otsuki et al. 2007).
Age
It usually affects women in the seventh decade, with a mean age of 73.2 years (Maluf and Koerner 1995).
Sex
It is more frequently observed in female patients, but it has been sporadically described in men (Nassar et al. 2006).
Side
SPC is typically unifocal and localized in the central region of the breast (Guo et al. 2016), although a single...
References and Further Reading
Burt, M., Madan, R., & Fan, F. (2016). Metastatic gastrinoma in the breast mimicking primary solid papillary carcinoma. Human Pathology, 56, 143ā146.
Cui, X., & Wei, S. (2015). Composite encapsulated papillary carcinoma and solid papillary carcinoma. Pathology International, 65, 133ā137.
Duprez, R., Wilkerson, P. M., Lacroix-Triki, M., Lambros, M. B., MacKay, A., AāHern, R., Gauthier, A., et al. (2012). Immunophenotypic and genomic characterization of papillary carcinomas of the breast. The Journal of Pathology, 226, 427ā441.
Guo, S., Wang, Y., Rohr, J., Fan, C., Li, Q., Li, X., & Wang, Z. (2016). Solid papillary carcinoma of the breast: A special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment. The Breast, 26, 67ā72.
Lakhani, S. R., Ellis, I. O., Schnitt, S. J., Tan, P. H., van de Vijver, M. J. (2012). WHO classification of tumours of the breast. World Health Organization classification of tumours. Lyon, IARC press. ISBN-10: 9283224337.
Maluf, H. M., & Koerner, F. C. (1995). Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. The American Journal of Surgical Pathology, 19, 1237ā1244.
Nassar, H., Qureshi, H., Adsay, N. V., Volkanadsay, N., & Visscher, D. (2006). Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. The American Journal of Surgical Pathology, 30, 501ā507.
Ni, Y. B., & Tse, G. M. (2016). Pathological criteria and practical issues in papillary lesions of the breast ā A review. Histopathology, 68, 22ā32.
Otsuki, Y., Yamada, M., Shimizu, S., Suwa, K., Yoshida, M., Tanioka, F., Ogawa, H., et al. (2007). Solid-papillary carcinoma of the breast: Clinicopathological study of 20 cases. Pathology International, 57, 421ā429.
Piscuoglio, S., Ng, C. K. Y., Martelotto, L. G., Eberle, C. A., Cowell, C. F., Natrajan, R., Bidard, F. C., et al. (2014). Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Molecular Oncology, 8, 1588ā1602.
Rabban, J. T., Koerner, F. C., & Lerwill, M. F. (2006). Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: A potentially difficult distinction resolved by cytokeratin 5/6. Human Pathology, 37, 787ā793.
Tan, B. Y., Thike, A. A., Ellis, I. O., & Tan, P. H. (2016). Clinicopathologic characteristics of solid papillary carcinoma of the breast. American Journal of Surgical Pathology, 40, 1334ā1342.
Turashvili, G., Brogi, E., Morrow, M., Hudis, C., Dickler, M., Norton, L., & Wen, H. Y. (2017). The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis. Breast Cancer Research and Treatment, 165, 65ā76.
Wei, S. (2016). Papillary lesions of the breast: An update. Archives of Pathology & Laboratory Medicine, 140, 628ā643.
Yoshimura, N., Murakami, S., Kaneko, M., Sakatani, A., Hirabayashi, N., & Takiyama, W. (2013). Synchronous bilateral solid papillary carcinomas of the breast. Case Reports in Surgery, 2013, 812129.
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Vissio, E., MarchiĆ², C., Sapino, A. (2019). Solid Papillary Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4760-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4760-1
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