Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Solid Papillary Carcinoma

  • Elena Vissio
  • Caterina Marchiò
  • Anna SapinoEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4760-1

Synonyms

Definition

Solid papillary carcinoma (SPC) is described in the 2012 WHO classification within the group of the intraductal papillary lesions and is defined as a variant of papillary carcinoma characterized by multiple solid nodules of neoplastic cells arranged around multiple fibrovascular spaces. Despite the lack of the external myoepithelial layer, these lesions are currently considered as noninvasive (Lakhani et al. 2012). However, cases of true invasive SPC exist.

Clinical Features

  • Incidence

    SPC is a rare entity, accounting for 1–2% of breast carcinomas (BCs) (Otsuki et al. 2007).

  • Age

    It usually affects women in the seventh decade, with a mean age of 73.2 years (Maluf and Koerner 1995).

  • Sex

    It is more frequently observed in female patients, but it has been sporadically described in men (Nassar et al. 2006).

  • Side

    SPC is typically unifocal and localized in the central region of the breast (Guo et al. 2016), although a single...

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References and Further Reading

  1. Burt, M., Madan, R., & Fan, F. (2016). Metastatic gastrinoma in the breast mimicking primary solid papillary carcinoma. Human Pathology, 56, 143–146.CrossRefGoogle Scholar
  2. Cui, X., & Wei, S. (2015). Composite encapsulated papillary carcinoma and solid papillary carcinoma. Pathology International, 65, 133–137.CrossRefGoogle Scholar
  3. Duprez, R., Wilkerson, P. M., Lacroix-Triki, M., Lambros, M. B., MacKay, A., A’Hern, R., Gauthier, A., et al. (2012). Immunophenotypic and genomic characterization of papillary carcinomas of the breast. The Journal of Pathology, 226, 427–441.CrossRefGoogle Scholar
  4. Guo, S., Wang, Y., Rohr, J., Fan, C., Li, Q., Li, X., & Wang, Z. (2016). Solid papillary carcinoma of the breast: A special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment. The Breast, 26, 67–72.CrossRefGoogle Scholar
  5. Lakhani, S. R., Ellis, I. O., Schnitt, S. J., Tan, P. H., van de Vijver, M. J. (2012). WHO classification of tumours of the breast. World Health Organization classification of tumours. Lyon, IARC press. ISBN-10: 9283224337.Google Scholar
  6. Maluf, H. M., & Koerner, F. C. (1995). Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. The American Journal of Surgical Pathology, 19, 1237–1244.CrossRefGoogle Scholar
  7. Nassar, H., Qureshi, H., Adsay, N. V., Volkanadsay, N., & Visscher, D. (2006). Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. The American Journal of Surgical Pathology, 30, 501–507.CrossRefGoogle Scholar
  8. Ni, Y. B., & Tse, G. M. (2016). Pathological criteria and practical issues in papillary lesions of the breast – A review. Histopathology, 68, 22–32.CrossRefGoogle Scholar
  9. Otsuki, Y., Yamada, M., Shimizu, S., Suwa, K., Yoshida, M., Tanioka, F., Ogawa, H., et al. (2007). Solid-papillary carcinoma of the breast: Clinicopathological study of 20 cases. Pathology International, 57, 421–429.CrossRefGoogle Scholar
  10. Piscuoglio, S., Ng, C. K. Y., Martelotto, L. G., Eberle, C. A., Cowell, C. F., Natrajan, R., Bidard, F. C., et al. (2014). Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Molecular Oncology, 8, 1588–1602.CrossRefGoogle Scholar
  11. Rabban, J. T., Koerner, F. C., & Lerwill, M. F. (2006). Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: A potentially difficult distinction resolved by cytokeratin 5/6. Human Pathology, 37, 787–793.CrossRefGoogle Scholar
  12. Tan, B. Y., Thike, A. A., Ellis, I. O., & Tan, P. H. (2016). Clinicopathologic characteristics of solid papillary carcinoma of the breast. American Journal of Surgical Pathology, 40, 1334–1342.CrossRefGoogle Scholar
  13. Turashvili, G., Brogi, E., Morrow, M., Hudis, C., Dickler, M., Norton, L., & Wen, H. Y. (2017). The 21-gene recurrence score in special histologic subtypes of breast cancer with favorable prognosis. Breast Cancer Research and Treatment, 165, 65–76.CrossRefGoogle Scholar
  14. Wei, S. (2016). Papillary lesions of the breast: An update. Archives of Pathology & Laboratory Medicine, 140, 628–643.CrossRefGoogle Scholar
  15. Yoshimura, N., Murakami, S., Kaneko, M., Sakatani, A., Hirabayashi, N., & Takiyama, W. (2013). Synchronous bilateral solid papillary carcinomas of the breast. Case Reports in Surgery, 2013, 812129.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Elena Vissio
    • 1
  • Caterina Marchiò
    • 1
    • 2
  • Anna Sapino
    • 1
    • 2
    Email author
  1. 1.Department of Medical SciencesUniversity of TorinoTorinoItaly
  2. 2.Candiolo Cancer Institute FPO-IRCCSUnit of PathologyCandioloItaly