Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Invasive Oncocytic Carcinoma

  • Dario de Biase
  • Moira RagazziEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4759-1



Invasive oncocytic carcinoma (OC) is a “special type” of breast carcinoma that is composed of at least 70% of cells with oncocytic features (so-called oncocytes) on both morphologic and immunophenotypic grounds (Lakhani et al. 2012).

Oncocyte is a Greek term, first applied to salivary glands by Hamperl (1931) in 1931, which means “swollen cell.” Under light microscope, oncocytes are characterized by abundant granular eosinophilic cytoplasm due to a high content of mitochondria, demonstrable at ultrastructural level (Roth et al. 1962). By definition, mitochondria must occupy at least 60% of the total cytoplasmic volume (Ghadially 1985) and confer an intense cytoplasmic granular positivity for anti-mitochondrion antibody (Damiani et al. 1998; Ragazzi et al. 2011). Namely, a carcinoma can be classified as oncocytic if it shows a strong cytoplasmic positivity for anti-mitochondrion antibody in at least 70% of tumor cells.

Clinical Features

  • Incidence

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References and Further Reading

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Authors and Affiliations

  1. 1.Department of Pharmacy and BiotechnologyUniversity of BolognaBolognaItaly
  2. 2.Department of Oncology and Advanced Technologies, Operative Unit of PathologyAzienda USL-IRCCSReggio EmiliaItaly