Inflammatory Myofibroblastoma of the Breast
Inflammatory myofibroblastic tumor (IMT) is currently classified by WHO as a soft tissue tumor composed of spindly myofibroblasts admixed with inflammatory cells such as plasma cells, lymphocytes, and eosinophils (Coffin and Fletcher 2013). IMT can occur in adults at several anatomic sites, including the breast. Although initially thought to be an exaggerated inflammatory local response to various stimuli, and thus variably labeled as “inflammatory pseudotumor (IP) or plasma cell granuloma,” there is growing evidence that a subset of these lesions are truly neoplastic in nature with the tendency to recur in up to 25% of the cases and with a slight risk of distant metastasis. This is especially true if IMT typically arises in the lung and abdomen of children/adolescents (Coffin and Fletcher 2013). As future studies are needed to better define the boundaries between a reactive and a neoplastic process, the combined...
References and Further Reading
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- Coffin, C. M., & Fletcher, J. A. (2013). Inflammatory myofibroblastic tumour. In C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, & F. Mertens (Eds.), WHO classification of tumours of soft tissue and bone (4th ed., pp. 83–84). Lyon: WHO Press.Google Scholar
- Vecchio, G. M., Amico, P., Grasso, G., Vasquez, E., La Greca, G., & Magro, G. (2011). Post-traumatic inflammatory pseudotumor of the breast with atypical morphological features: A potential diagnostic pitfall. Report of a case and a critical review of the literature. Pathology, Research and Practice, 207, 322–326.CrossRefGoogle Scholar