Encapsulated Papillary Carcinoma
Encapsulated papillary carcinoma (EPC) was described for the first time in 1969 as a papillary entity arising from the ductal–lobular system, developing in a cyst, and surrounded by a fibrous capsule.
The WHO Working Group, in the fourth edition, considered EPC as a malignant non-invasive neoplastic ductal proliferation with a papillary architecture circumscribed by a fibrous capsule (Lakhani et al. 2012). However, cases of EPC may show invasion.
EPC is an extremely uncommon type of carcinoma and it accounts less than 2% of all breast cancers (Li et al. 2018).
It generally affects postmenopausal women; the mean age at diagnosis is around 65–70 years (Mogal et al. 2016).
This malignancy is frequently diagnosed in female patients, but EPCs have also been described in men.
EPC is usually unifocal. It may arise in the larger and more centrally placed ducts, often...
References and Further Reading
- Duprez, R., Wilkerson, P. M., Lacroix-Triki, M., Lambros, M. B., MacKay, A., Hern, R. A., Gauthier, A., Pawar, V., Colombo, P. E., Daley, F., Natrajan, R., Ward, E., MacGrogan, G., Arbion, F., Michenet, P., Weigelt, B., Vincent-Salomon, A., & Reis-Filho, J. S. (2012). Immunophenotypic and genomic characterization of papillary carcinomas of the breast. The Journal of Pathology, 226, 427–441.CrossRefGoogle Scholar
- Fayanju, O. M., Ritter, J., Gillanders, W. E., Eberlein, T. J., Dietz, J. R., Aft, R., & Margenthaler, J. A. (2007). Therapeutic management of intracystic papillary carcinoma of the breast: The roles of radiation and endocrine therapy. The American Journal of Surgery, 194, 497–500.CrossRefGoogle Scholar
- Lakhani, S.R., Ellis, I.O., Schnitt, S.J., Tan, P.H., & van de Vijver, M.J.. (2012). WHO classification of tumors of the breast (pp. 106–107). World Health Organization. ISBN-10: 9283224337. Lyon, IARC press.Google Scholar
- Rakha, E. A., Gandhi, N., Climent, F., van Deurzen, C. H., Haider, S. A., Dunk, L., Lee, A. H., Macmillan, D., & Ellis, I. O. (2011). Encapsulated papillary carcinoma of the breast: An invasive tumor with excellent prognosis. The American Journal of Surgical Pathology, 35, 1093–1103.CrossRefGoogle Scholar
- Solorzano, C. C., Middleton, L. P., Hunt, K. K., Mirza, N., Meric, F., Kuerer, H. M., Ross, M. I., Ames, F. C., Feig, B. W., Pollock, R. E., Singletary, S. E., & Babiera, G. (2002). Treatment and outcome of patients with intracystic papillary carcinoma of the breast. The American Journal of Surgery, 184, 364–368.CrossRefGoogle Scholar