Definition
Benign proliferative lesion within terminal ductal lobular units that typically shows lumen filled by cells arranged in a streaming-like fashion and peripheral slit-like spaces. Rarely usual ductal hyperplasia (UDH) may show an infiltrative pattern of growth (see “Microscopy”).
Clinical Features
Impalpable lesion. No specific clinical features are described being a microscopic finding.
Incidence
UDH is a common finding in fibrocystic changes of the breast and may be seen in papillomas.
Age
All ages may be affected. Infiltrative epitheliosis is more frequent in postmenopausal age (range 54–80 years).
Sex
It usually occurs in female breast, but it can be rarely observed in male breast.
Site
No specific site is identified; this lesion can occur anywhere within the breast parenchyma.
Imaging
Specific radiological patterns are not...
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References and Further Reading
Ang, D. C., Warrick, A. L., Shilling, A., Beadling, C., Corless, C. L., & Troxell, M. L. (2014). Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions. Modern Pathology, 27, 740–750.
Eberle, C. A., Piscuoglio, S., Rakha, E. A., Ng, C. K., Geyer, F. C., Edelweiss, M., Sakr, R. A., Weigelt, B., Reis-Filho, J. S., & Ellis, I. O. (2016). Infiltrating epitheliosis of the breast: Characterization of histological features, immunophenotype and genomic profile. Histopathology, 68, 1030–1039.
Eusebi, V., & Millis, R. R. (2010). Epitheliosis, infiltrating epitheliosis, and radial scar. Seminar in Diagnotic Pathology, 27, 5–12.
Martinez, A. P., Cohen, C., Hanley, K. Z., & Li, X. B. (2016). Estrogen receptor and cytokeratin 5 are reliable markers to separate usual ductal hyperplasia from atypical ductal hyperplasia and low-grade ductal carcinoma in situ. Archive of Pathology and Laboratory Medicine, 140, 686–689.
Otterbach, F., Bankfalvi, A., Bergner, S., Decker, T., Krech, R., & Boecker, W. (2000). Cytokeratin 5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast. Histopathology, 37, 232–240.
Rabban, J. T., Koerner, F. C., & Lerwill, M. F. (2006). Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: A potentially difficult distinction resolved by cytokeratin 5/6. Human Pathology, 37, 787–793.
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Sapino, A., Balmativola, D., Disanto, M.G., Marchiò, C. (2019). Usual Ductal Hyperplasia (UDH). In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4731-2
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4731-2
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Usual Ductal Hyperplasia (UDH)- Published:
- 20 December 2018
DOI: https://doi.org/10.1007/978-3-319-28845-1_4731-2
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Original
Usual Ductal Hyperplasia (UDH)- Published:
- 20 November 2018
DOI: https://doi.org/10.1007/978-3-319-28845-1_4731-1