Usual Ductal Hyperplasia (UDH)
Benign proliferative lesion within terminal ductal lobular units that typically shows lumen filled by cells arranged in a streaming-like fashion and peripheral slit-like spaces. Rarely usual ductal hyperplasia (UDH) may show an infiltrative pattern of growth (see “Microscopy”).
UDH is a common finding in fibrocystic changes of the breast and may be seen in papillomas.
All ages may be affected. Infiltrative epitheliosis is more frequent in postmenopausal age (range 54–80 years).
It usually occurs in female breast, but it can be rarely observed in male breast.
No specific site is identified; this lesion can occur anywhere within the breast parenchyma.
Specific radiological patterns are not...
References and Further Reading
- Eberle, C. A., Piscuoglio, S., Rakha, E. A., Ng, C. K., Geyer, F. C., Edelweiss, M., Sakr, R. A., Weigelt, B., Reis-Filho, J. S., & Ellis, I. O. (2016). Infiltrating epitheliosis of the breast: Characterization of histological features, immunophenotype and genomic profile. Histopathology, 68, 1030–1039.CrossRefGoogle Scholar
- Martinez, A. P., Cohen, C., Hanley, K. Z., & Li, X. B. (2016). Estrogen receptor and cytokeratin 5 are reliable markers to separate usual ductal hyperplasia from atypical ductal hyperplasia and low-grade ductal carcinoma in situ. Archive of Pathology and Laboratory Medicine, 140, 686–689.CrossRefGoogle Scholar