Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Usual Ductal Hyperplasia (UDH)

  • Anna SapinoEmail author
  • Davide Balmativola
  • Maria Giulia Disanto
  • Caterina Marchiò
Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-3-319-28845-1_4731-2



Benign proliferative lesion within terminal ductal lobular units that typically shows lumen filled by cells arranged in a streaming-like fashion and peripheral slit-like spaces. Rarely usual ductal hyperplasia (UDH) may show an infiltrative pattern of growth (see “Microscopy”).

Clinical Features

Impalpable lesion. No specific clinical features are described being a microscopic finding.
  • Incidence

    UDH is a common finding in fibrocystic changes of the breast and may be seen in papillomas.

  • Age

    All ages may be affected. Infiltrative epitheliosis is more frequent in postmenopausal age (range 54–80 years).

  • Sex

    It usually occurs in female breast, but it can be rarely observed in male breast.

  • Site

    No specific site is identified; this lesion can occur anywhere within the breast parenchyma.

  • Imaging

    Specific radiological patterns are not...

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References and Further Reading

  1. Ang, D. C., Warrick, A. L., Shilling, A., Beadling, C., Corless, C. L., & Troxell, M. L. (2014). Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions. Modern Pathology, 27, 740–750.CrossRefGoogle Scholar
  2. Eberle, C. A., Piscuoglio, S., Rakha, E. A., Ng, C. K., Geyer, F. C., Edelweiss, M., Sakr, R. A., Weigelt, B., Reis-Filho, J. S., & Ellis, I. O. (2016). Infiltrating epitheliosis of the breast: Characterization of histological features, immunophenotype and genomic profile. Histopathology, 68, 1030–1039.CrossRefGoogle Scholar
  3. Eusebi, V., & Millis, R. R. (2010). Epitheliosis, infiltrating epitheliosis, and radial scar. Seminar in Diagnotic Pathology, 27, 5–12.CrossRefGoogle Scholar
  4. Martinez, A. P., Cohen, C., Hanley, K. Z., & Li, X. B. (2016). Estrogen receptor and cytokeratin 5 are reliable markers to separate usual ductal hyperplasia from atypical ductal hyperplasia and low-grade ductal carcinoma in situ. Archive of Pathology and Laboratory Medicine, 140, 686–689.CrossRefGoogle Scholar
  5. Otterbach, F., Bankfalvi, A., Bergner, S., Decker, T., Krech, R., & Boecker, W. (2000). Cytokeratin 5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast. Histopathology, 37, 232–240.CrossRefGoogle Scholar
  6. Rabban, J. T., Koerner, F. C., & Lerwill, M. F. (2006). Solid papillary ductal carcinoma in situ versus usual ductal hyperplasia in the breast: A potentially difficult distinction resolved by cytokeratin 5/6. Human Pathology, 37, 787–793.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Anna Sapino
    • 1
    • 2
    Email author
  • Davide Balmativola
    • 1
  • Maria Giulia Disanto
    • 1
  • Caterina Marchiò
    • 1
  1. 1.Unit of PathologyCandiolo Cancer Institute – FPO IRCCsCandioloItaly
  2. 2.Department of Medical SciencesUniversity of TorinoTurinItaly