Invasive Carcinoma with Medullary Features
The WHO Classification of Tumors of the Breast recommends the use of the collective term “Carcinoma with Medullary Features” to encompass tumors previously diagnosed as classical medullary carcinoma (classical MC), atypical medullary carcinoma (atypical MC), and a subgroup of invasive breast carcinoma of no special type (NST) with medullary characteristics (Lakhani et al. 2012).
An expansile or pushing border
A syncytial growth pattern
High cytonuclear grade
A prominent lymphoplasmacytic infiltrate
These diagnostic criteria are less strict than the original criteria proposed by Ridolfi et al. for a diagnosis of classical MC which requires complete circumscription, a...
References and Further Reading
- Dua, I., & Tan, A. R. (2017). Immunotherapy for triple-negative breast cancer: A focus on immune checkpoint inhibitors. American Journal of Haematology and Oncology, 13, 20–27.Google Scholar
- Ellis, I. O., Al-Sam, S., Anderson, N., Carder, P., Deb, R., Girling, A., et al. (2016). Pathology reporting of breast disease in surgical excision specimens incorporating the dataset for histological reporting of breast cancer. (2016). Rcpath.org. Available from: http://www.rcpath.org. Accessed Sept 2017.
- Hicks, D. G., & Lester, S. C. (2017). Carcinoma with medullary features. Available from: https://app.expertpath.com. Accessed Sept 2014.
- Huober, J., Gelber, S., Coates, A. S., Viale, G., Ohlschlegel, C., et al. (2012). Prognosis of medullary breast cancer: Analyses of 13 international breast cancer study group (IBCSG) trials. Journal of Clinical Oncology, 11, 2843–2851.Google Scholar
- Lakhani, S., Ellis, I. O., Schnitt, S. J., Tan, P. H., & van de Vijver, M. J. (2012). WHO classification of tumours of the breast (pp. 46–47). Lyon: International Agency for Research on Cancer.Google Scholar
- Vincent-Salomon, A., Gruel, N., Lucchesi, C., MacGrogan, G., Dendale, R., Sigal-Zafrani, B., et al. (2007). Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entity. Breast Cancer Research, 9, R24.CrossRefGoogle Scholar