Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Ductal Carcinoma In Situ

  • Isabella CastellanoEmail author
  • Jasna Metovic
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4706-1



Ductal carcinoma in situ (DCIS) is a neoplastic proliferation confined to the mammary ductal-lobular system, which is surrounded by a myoepithelial layer and a basal membrane. DCIS covers a heterogeneous group of diseases characterized by subtle to marked cytological atypia, without any invasion of the stromal tissue (Lakhani et al. 2012).

Clinical Features


DCIS incidence gradually and constantly increased over the past decades (from 5.8 per 100,000 women in 1975 to 34.4 per 100,000 women in 2014), according to data of the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program (SEER 2014). DCIS consequently constitutes around 20% of all breast cancer diagnoses.

The widespread use of mammography, as well as implementation of national breast screening programs (Ernster and Barclay 1997), contributed to the diagnosis...

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References and Further Reading

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medical SciencesUniversity of TurinTurinItaly
  2. 2.Department of OncologyUniversity of TurinTurinItaly