Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Histiocytic Neoplasma

  • Stefano A. PileriEmail author
  • Valentina Tabanelli
  • Claudio Agostinelli
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_3863-1


In the fourth edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Swerdlow et al. 2017), neoplasms derived from histiocytes and dendritic cells (HDCT) were gathered together based on the functional properties of their normal counterpart (i.e., phagocytosis, processing and presentation of antigens to lymphoid elements, etc.) more than histogenesis. In fact, although most of these elements derive from a common myeloid precursor, some recognize a mesenchymal origin (e.g., follicular dendritic cells). Importantly, HDCT tend to reproduce the morphologic, phenotypic, and ultrastructural characteristics of terminally differentiated elements, i.e., mature histiocytes and different categories of dendritic cells. In line with this, in the fourth edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, blastic plasmacytoid dendritic cell tumor (Swerdlow et al. 2017; Marafioti et al. 2008) was excluded from the HDCT chapter...

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Stefano A. Pileri
    • 1
    • 2
    Email author
  • Valentina Tabanelli
    • 2
  • Claudio Agostinelli
    • 3
  1. 1.Bologna UniversityBolognaItaly
  2. 2.European Institute of OncologyMilanItaly
  3. 3.Department of Experimental, Diagnostic and Specialty MedicineBologna University School of MedicineBolognaItaly