Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Peliosis, Spleen

  • Alexander MarxEmail author
  • Thomas Rüdiger
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_3847-1


Peliosis of the spleen is a non-neoplastic, multifocal, commonly splenomegalic, and highly rupture-prone process of unknown etiology and enigmatic pathogenesis that arises in the splenic red pulp and leads to multiple, blood-filled, cyst-like cavities that are lined by sinus wall cells or dissolved red pulp cords but not endothelial or epithelial cells.

Peliosis of the spleen is mostly associated with the commoner peliosis of the liver and, rarely, peliosis of other organs (Renard et al. 2012; Diebold and Audouin 1983). Bacillary angiomatosis of the spleen has been called “peliosis” by some authors. However, it is a capillary proliferation due to the suppurative infection of the spleen caused by Bartonella species. It does not fulfill the above criteria and is not covered here.

Clinical Features

  • Incidence and Clinical Symptoms

    The true incidence of peliosis of the spleen is unknown. In a single series of 1200 randomly selected autopsies, the frequency of mainly microscopic...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Aubrey-Bassler, F. K., & Sowers, N. (2012). 613 cases of splenic rupture without risk factors or previously diagnosed disease: A systematic review. BMC Emergency Medicine, 12, 11.  https://doi.org/10.1186/1471-227X-12-11.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Benjamin, D. R., & Shunk, B. (1978). A fatal case of peliosis of the liver and spleen. American Journal of Diseases of Children, 132(2), 2017–2208.Google Scholar
  3. Diebold, J., & Audouin, J. (1983). Peliosis of the spleen. The American Journal of Surgical Pathology, 7(2), 197–204.CrossRefGoogle Scholar
  4. Martel, M., Ceuk, W., Lombardi, L., Lifschitz-Mercer, B., Chan, J. K., & Rosai, J. (2004). Sclerosing angiomatoid nodular transformation (SANT): Report of 25 cases of a distinct benign splenic lesion. The American Journal of Surgical Pathology, 28(10), 1268–1279.CrossRefGoogle Scholar
  5. Renard, C., Baumann, D., Thriat, S., Debiquis, A., Lindner, V., & Thiébault, S. (2012). Péliose splénique isolée: à propos d’un cas. Annales de Pathologie, 32(5), 379–383.CrossRefGoogle Scholar
  6. Tada, T., Wakabayashi, T., & Kishimoto, H. (1983). Peliosis of the spleen. American Journal of Clinical Pathology, 79(6), 708–713.CrossRefGoogle Scholar
  7. Tsokos, M., & Erbersdobler, A. (2005). Pathology of peliosis. Forensic Science International, 149(1), 25–33.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.PathologyUniversity Medical Centre Mannheim, Heidelberg UniversityMannheimGermany
  2. 2.PathologyStädtisches Klinikum KarlsruheKarlsruheGermany