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Encyclopedia of Pathology pp 1–5Cite as

Plasmablastic Lymphoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

DLBCL; Plasmablastic lymphoma of the oral cavity; Plasmablastic lymphoma of the oral cavity type

Definition

In 1992, Stein and Dallenbach for the first time used the term “plasmablastic lymphoma” (PBL). Plasmablastic lymphoma of the oral cavity was first reported in patients infected by HIV in 1997. Subsequently, this lymphoma was observed in other extranodal sites, predominantly in HIV-infected patients. Then, the term “plasmablastic lymphoma of the oral cavity type” was proposed. In 2001, plasmablastic lymphoma was included in the WHO classification as a rare subtype of diffuse large B-cell lymphoma (DLBCL), and, in 2008, it was incorporated into the WHO classification as a distinct entity (Stein et al. 2008; Campo et al. 2017).

Clinical Features

  • Incidence

    PBL together with primary central nervous system lymphoma (PCNSL) and primary effusion lymphoma (PEL) is a minor fraction (about 7–8 %) of DLBCL which represents about 70 % of the HIV-associated lymphomas (Wang et al. 2014)....

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References and Further Reading

  • Campo, E., Stein, H. & Harris, N.L. (2017) Plasmablastic lymphoma. In Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., Arber, T.A., Hasserjian, R.P., Le Beau, M.M., Orazi, A. & Siebert R, eds. WHO classification of tumours of haematopoietic and lymphoid tissues (pp 321–322) Revised 4th ed. Lyon: IARC.

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  • Carbone, A., Vaccher, E., Gloghini, A., Pantanowitz, L., Abayomi, A., de Paoli, P., & Franceschi, S. (2014). Diagnosis and management of lymphomas and other cancers in HIV-infected patients. Nature Reviews. Clinical Oncology, 11, 223–238.

    Article  CAS  PubMed Central  Google Scholar 

  • Castillo, J., Pantanowitz, L., & Dezube, B. J. (2008). HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases. American Journal of Hematology, 83, 804–809.

    Article  PubMed Central  Google Scholar 

  • Castillo, J. J., Bibas, M., & Miranda, R. N. (2015). The biology and treatment of plasmablastic lymphoma. Blood, 125, 2323–2330.

    Article  CAS  Google Scholar 

  • Medeiros, L.J, O’Malley, D.P., Caraway, N.P., Vega, F., Elenitoba-Johnson, K.S.J. & Lim, M.S. (2017) Plasmablastic lymphoma. In: Tumors of the lymph nodes and spleen (pp 375–388) AFIP Atlas of Tumor Pathology, 4th Series, Fascicle 25. Washington DC: American Registry of Pathology.

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  • Stein, H., Harris, N. L., & Campo, E. (2008). Plasmablastic lymphoma. In S. H. Swerdlow, E. Campo, N. L. Harris, E. S. Jaffe, S. A. Pileri, H. Stein, J. Thiele, & J. W. Vardiman (Eds.), WHO classification of tumours of haematopoietic and lymphoid tissues (4th ed., pp. 256–257). Lyon: IARC.

    Google Scholar 

  • Wang, H.-Y., Wong-Sefidan, I., & Reid, E. (2014). Plasmablastic lymphoma. In E. Yarchoan (Ed.), Cancers in people with HIV and AIDS (pp. 223–234). New York: Springer.

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Author information

Authors and Affiliations

  1. Department of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Aviano, Italy

    Antonino Carbone

  2. Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy

    Annunziata Gloghini

Authors
  1. Antonino Carbone
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  2. Annunziata Gloghini
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Corresponding author

Correspondence to Antonino Carbone .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Carbone, A., Gloghini, A. (2018). Plasmablastic Lymphoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_3834-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_3834-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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