Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Plasmablastic Lymphoma

  • Antonino CarboneEmail author
  • Annunziata Gloghini
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_3834-1



In 1992, Stein and Dallenbach for the first time used the term “plasmablastic lymphoma” (PBL). Plasmablastic lymphoma of the oral cavity was first reported in patients infected by HIV in 1997. Subsequently, this lymphoma was observed in other extranodal sites, predominantly in HIV-infected patients. Then, the term “plasmablastic lymphoma of the oral cavity type” was proposed. In 2001, plasmablastic lymphoma was included in the WHO classification as a rare subtype of diffuse large B-cell lymphoma (DLBCL), and, in 2008, it was incorporated into the WHO classification as a distinct entity (Stein et al. 2008; Campo et al. 2017).

Clinical Features

  • Incidence

    PBL together with primary central nervous system lymphoma (PCNSL) and primary effusion lymphoma (PEL) is a minor fraction (about 7–8 %) of DLBCL which represents about 70 % of the HIV-associated lymphomas (Wang et al. 2014)....

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References and Further Reading

  1. Campo, E., Stein, H. & Harris, N.L. (2017) Plasmablastic lymphoma. In Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., Arber, T.A., Hasserjian, R.P., Le Beau, M.M., Orazi, A. & Siebert R, eds. WHO classification of tumours of haematopoietic and lymphoid tissues (pp 321–322) Revised 4th ed. Lyon: IARC.Google Scholar
  2. Carbone, A., Vaccher, E., Gloghini, A., Pantanowitz, L., Abayomi, A., de Paoli, P., & Franceschi, S. (2014). Diagnosis and management of lymphomas and other cancers in HIV-infected patients. Nature Reviews. Clinical Oncology, 11, 223–238.CrossRefPubMedCentralGoogle Scholar
  3. Castillo, J., Pantanowitz, L., & Dezube, B. J. (2008). HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases. American Journal of Hematology, 83, 804–809.CrossRefPubMedCentralGoogle Scholar
  4. Castillo, J. J., Bibas, M., & Miranda, R. N. (2015). The biology and treatment of plasmablastic lymphoma. Blood, 125, 2323–2330.CrossRefGoogle Scholar
  5. Medeiros, L.J, O’Malley, D.P., Caraway, N.P., Vega, F., Elenitoba-Johnson, K.S.J. & Lim, M.S. (2017) Plasmablastic lymphoma. In: Tumors of the lymph nodes and spleen (pp 375–388) AFIP Atlas of Tumor Pathology, 4th Series, Fascicle 25. Washington DC: American Registry of Pathology.Google Scholar
  6. Stein, H., Harris, N. L., & Campo, E. (2008). Plasmablastic lymphoma. In S. H. Swerdlow, E. Campo, N. L. Harris, E. S. Jaffe, S. A. Pileri, H. Stein, J. Thiele, & J. W. Vardiman (Eds.), WHO classification of tumours of haematopoietic and lymphoid tissues (4th ed., pp. 256–257). Lyon: IARC.Google Scholar
  7. Wang, H.-Y., Wong-Sefidan, I., & Reid, E. (2014). Plasmablastic lymphoma. In E. Yarchoan (Ed.), Cancers in people with HIV and AIDS (pp. 223–234). New York: Springer.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of PathologyCentro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCSAvianoItaly
  2. 2.Department of Diagnostic Pathology and Laboratory MedicineFondazione IRCCS, Istituto Nazionale TumoriMilanItaly