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Synovial Sarcoma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 121 Accesses

Synonyms

Malignant synovioma; Synovial cell sarcoma

Definition

Synovial sarcoma (SS) is a malignant mesenchymal tumor showing varying degrees of epithelial differentiation. Despite the designation, it does not originate from synovium, and neoplastic cells do not show evidence of differentiation toward a synovial phenotype.

Clinical Features

  • Incidence

    SS originating in the genitourinary tract is rare.

  • Age

    It occurs in young adults and adults, with median age in the fourth decade.

  • Sex

    There is no significant gender predilection.

  • Site

    Genitourinary SSs arise more frequently in the kidney, but few examples have also been reported in the prostate, the spermatic cord, and the penis.

  • Treatment

    Surgery is the primary treatment, but adjuvant radiotherapy and chemotherapy may also be employed in selected cases.

  • Outcome

    SS is an aggressive tumor with frequent distant metastases and poor survival. In a review of 64 patients with SS of the kidney, the median overall survival was 48 months. Patients...

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References and Further Reading

  • Argani, P., Faria, P. A., Epstein, J. I., Reuter, V. E., Perlman, E. J., Beckwith, J. B., & Ladanyi, M. (2000). Primary renal synovial sarcoma: Molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney. The American Journal of Surgical Pathology, 24, 1087–1096.

    Article  CAS  Google Scholar 

  • Iacovelli, R., Altavilla, A., Ciardi, A., Urbano, F., Manai, C., Gentile, V., & Cortesi, E. (2012). Clinical and pathological features of primary renal synovial sarcoma: Analysis of 64 cases from 11 years of medical literature. BJU International, 110, 1449–1454.

    Article  Google Scholar 

  • Olofson, A. M., & Linos, K. (2017). Primary intraprostatic synovial sarcoma. Archives of Pathology & Laboratory Medicine, 141, 301–304.

    Article  Google Scholar 

  • Sasso, F., Delicato, G., Gentile, G., Falabella, R., & Gentile, V. (2002). Primary synovial sarcoma of the penis. The Journal of Urology, 168(2), 633. Erratum in: J Urol. 2003;169:622.

    Article  CAS  Google Scholar 

  • Schoolmeester, J. K., Cheville, J. C., & Folpe, A. L. (2014). Synovial sarcoma of the kidney: A clinicopathologic, immunohistochemical, and molecular genetic study of 16 cases. The American Journal of Surgical Pathology, 38, 60–65.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Alessandro Franchi

Authors
  1. Alessandro Franchi
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Corresponding author

Correspondence to Alessandro Franchi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Franchi, A. (2019). Synovial Sarcoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_3462-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_3462-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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