Microbotox, Mesobotox, Botulinum Toxin Microdroplets

  • Bhertha TamuraEmail author
Living reference work entry

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Part of the Clinical Approaches and Procedures in Cosmetic Dermatology book series (CAPCD)


Microdroplets of botulinum toxin, also called microbotox or mesobotox, is the injection of multiple microdroplets or microinjection of a diluted botulinum toxin (BTX) solution into the dermis or the interface between the dermis and the superficial layer of the facial muscles, glands, and skin structures. This technique can be considered a new approach for botulinum toxin treatment; therefore, new studies to define the protocols are necessary. The indications for this method are quite similar to those common aesthetics indications for BTX, but in some cases it might be a good choice for a better outcome without excessive muscle relaxation. Topical anesthetics can be applied before this treatment, as it involves multiple punctures and some patients might complain about pain. This chapter will describe the suggestions and techniques reported in the literature and our personal experience. We have been using this technique since our publication in 2004, in which we described the results of BTX injection for the treatment of cutis laxa and explained the intimate relationship of the muscle fibers and the SMAS (Superficial Musculoaponeurotic System).


Mesobotox Microbotox Botulinum toxin microdroplets Botulinum toxin microinjection Mesotherapy SMAS Topical botulinum toxin 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Clínicas Hospital of São Paulo of the University of Sao PauloSao PauloBrazil
  2. 2.Barradas and Bourroul’s Ambulatório de Especialidades in Sao PauloSao PauloBrazil
  3. 3.Sorocaba’s Ambulatório de Especialidade in SorocabaSao PauloBrazil

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