Encyclopedia of Evolutionary Psychological Science

Living Edition
| Editors: Todd K. Shackelford, Viviana A. Weekes-Shackelford

Long-Term Potentiation

  • Androulla Ioannou
  • Xenia Anastassiou-HadjicharalambousEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-16999-6_1033-1


Long-term potentiation refers to the persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse.


Long-term potentiation of synaptic transmission is a major mechanism for investigating learning and memory in the synaptic level. It is found in several regions of the brain, with the most prominent being the hippocampus thus its obvious involvement in the neural basis of some forms of memory Cooke & Bliss (2006).

Properties of Long-Term Potentiation

High frequency stimulation causes an increase in the efficiency of synaptic transmission, therefore enhancing the efficiency of the signal. For the induction of long-term potentiation, the activation of excitatory receptors is required Cooke & Bliss (2006). Bliss and Collingridge (1993) reported on the properties of long-term potentiation that differentiates it from other forms of synaptic plasticity: input specificity (it does not spread to other synapses), associativity(when a...

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  1. Bliss, T. V., & Collingridge, G. L. (1993). A synaptic model of memory: Long-term potentiation in the hippocampus. Nature, 361(6407), 31.CrossRefPubMedGoogle Scholar
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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Androulla Ioannou
    • 1
  • Xenia Anastassiou-Hadjicharalambous
    • 1
    Email author
  1. 1.University of NicosiaNicosiaCyprus

Section editors and affiliations

  • Menelaos Apostolou
    • 1
  1. 1.University of NicosiaNicosiaCyprus