Intestine Retransplantation in the Intestine or Liver-Intestine Recipient

Reference work entry
Part of the Organ and Tissue Transplantation book series (OTT)

Abstract

In the last 25 years, intestinal transplantation moved from an experimental procedure to an established treatment option for patients with irreversible intestinal failure and life-threatening complication of total parenteral nutrition. Intestinal transplantation is the only treatment that can potentially cure the baseline disease and reestablish the normal physiology and anatomy for those patients (Abu-Elmagd, Gastroenterology 130:132–137, 2006). Over the last 20 years, there have been significant advances in immunosuppression regimens leading to excellent short-term outcomes. However, chronic rejection persists as one of the major causes of graft loss (Grant et al, Ann Surg 241:607–613, 2005). A more complete understanding of the intestinal immunology and its association with graft failure continues to evolve. In addition to the immunological risks, intestinal retransplantation is one of the most challenging surgical procedures in the field.

Keywords

Retransplantation Intestine retransplantation Small bowel transplant Chronic rejection of the intestine Multivisceral transplant Graft loss 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Miami Transplant InstituteUniversity of Miami Miller School of Medicine, Jackson Memorial HospitalMiamiUSA

Section editors and affiliations

  • George Mazariegos
    • 1
  • Donna Basille
    • 2
  1. 1.Children's Hospital of PittsburghPittsburghUSA
  2. 2.University of Pittsburgh Medical CenterPittsburghUSA

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