2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Stone Granuloma

  • Maria Rosaria RaspolliniEmail author
  • Antonio Lopez-Beltran
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4952


Ureteral stricture


Progressive ureteral obstruction subsequent to ureteroscopic stone removal

Clinical Features

  • Incidence

    Uncommon. Seen most frequently in patients undergoing endourological work-up to remove ureteral stones (Dretler and Young 1993). Fragmentation of calculi during the procedure may cause particle of mineral salts phagocytized by foreign body giant cells and macrophages, followed by fibrosis, then resulting in ureter obstruction because of a granuloma embedded in the ureteral wall (Doddamani et al. 2002).

  • Age

    Adult age

  • Sex

    More common in the males

  • Site


  • Treatment

    The stricture is irreversible and it requires surgical treatment.

  • Outcome

    Benign outcome


Ureteral thickening causing ureteric stricture (Fam et al. 2015).


Granuloma with foreign body giant cells and macrophages embedded in the ureter wall causing ureter obstruction.


Macrophages stain with CD68.

Differential Diagnosis

Conventional urothelial...

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References and Further Reading

  1. Doddamani, D., Kumar, R., & Hemal, A. K. (2002). Stone granuloma – Not to be forgotten as a delayed complication of ureteroscopy. Urologia Internationalis, 68, 129–131.PubMedCrossRefGoogle Scholar
  2. Dretler, S. P., & Young, R. H. (1993). Stone granuloma: A cause of ureteral stricture. The Journal of Urology, 150, 1800–1802.PubMedCrossRefGoogle Scholar
  3. Fam, X. I., Singam, P., Ho, C. C., et al. (2015). Ureteral stricture formation after ureteroscope treatment of impacted calculi: A prospective study. Korean Journal of Urology, 56, 63–67.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Maria Rosaria Raspollini
    • 1
    Email author
  • Antonio Lopez-Beltran
    • 2
    • 3
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain