2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Spermatic Cord Cellular Angiofibroma

  • Raffaele Gaeta
  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4942


Angiomyofibroblastoma-like tumor


Rare, circumscribed, slow-growing, benign mesenchymal tumor whose suggested histogenesis is perivascular stem cells.

Clinical Features

  • Incidence

    Very low. About 60 cases of cellular angiofibroma in male genitourinary system are reported in English literature.

  • Age

    It affects adults usually over 50 years of age.

  • Site

    In men, cellular angiofibroma is observed in the inguino-scrotal region (paratesticular, tunica vaginalis, epididymis, and spermatic cord). There are rare reports of perineal, urethral, and retroperitoneal locations.

  • Treatment

    Recommended treatment is the complete surgical excision with tumor-free margins and long-term follow-up exams. No indications for radiation and chemotherapy.

  • Outcome

    Follow-up is required because it may recur years after initial resection. No metastases have been observed.


Macroscopic appearance is of a well-circumscribed, elastic-hard, slightly mobile mass whose size varies between 2.5 cm...

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References and Further Reading

  1. Aydin, M., Uzuner, H., Akgunes, E., et al. (2017). Cellular angiofibroma of the spermatic cord. Aktuelle Urologie, 48(2), 159–160.PubMedCrossRefGoogle Scholar
  2. Dikaiakos, P., Zizi-Sermpetzoglou, A., Rizos, S., & Marinis, A. (2011). Angiofibroma of the spermatic cord: A case report and a review of the literature. Journal of Medical Case Reports, 30(5), 423.CrossRefGoogle Scholar
  3. Iwasa, Y., & Fletcher, C. D. (2004). Cellular angiofibroma: Clinicopathologic and immunohistochemical analysis of 51 cases. The American Journal of Surgical Pathology, 28, 1426–1435.PubMedCrossRefGoogle Scholar
  4. Laskin, W. B., Fetsch, J. F., & Mostofi, F. K. (1998). Angiomyofibroblastomalike tumor of the male genital tract: Analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. The American Journal of Surgical Pathology, 22, 6–16.PubMedCrossRefGoogle Scholar
  5. Nucci, M. R., Granter, S. R., & Fletcher, C. D. (1997). Cellular angiofibroma: A benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. The American Journal of Surgical Pathology, 21, 636–644.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly