Synonyms
Bellini duct carcinoma
Definition
A highly malignant neoplasm arising from the principal cells of the renal collecting ducts of Bellini.
Clinical Features
Incidence
Collecting duct carcinoma is a rare tumor accounting for 1–2% of renal neoplasms.
Age
It occurs in a wide age range with the median age similar to the other renal carcinoma.
Sex
There is a slight male predominance.
Site
The tumor is centered on the renal medulla.
Treatment
Radical nephrectomy is the standard of care, often with local lymphadenectomy. Since metastases are frequently present at the moment of the diagnosis, the surgical excision is followed by chemotherapy.
Outcome
Frequently the patients are symptomatic, with lymph node involvement and metastases to the lungs, liver, bone, adrenals, and brain at the time of diagnosis.
Macroscopy
They are usually large and infiltrative, whitish, and firm tumors grossly located in the medulla or central parts of the kidney (Fleming and Lewi 1986).
Microscopy
Histologica...
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Fleming, S., & Lewi, H. J. (1986). Collecting duct carcinoma of the kidney. Histopathology, 10, 1131–1141.
Gupta, R., Billis, A., Shah, R. B., et al. (2012). Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma: Clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationship. The American Journal of Surgical Pathology, 36, 1265–1278.
Kobayashi, N., Matsuzaki, O., Shirai, S., et al. (2008). Collecting duct carcinoma of the kidney: An immunohistochemical evaluation of the use of antibodies for differential diagnosis. Human Pathology, 39, 1350–1359.
Ohe, C., Smith, S. C., Sirohi, D., et al. (2018). Reappraisal of morphologic differences between renal medullary carcinoma, collecting duct carcinoma, and fumarate hydratase-deficient renal cell carcinoma. The American Journal of Surgical Pathology, 42, 279–292.
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Caliò, A., Segala, D., Martignoni, G. (2020). Renal Collecting Duct Carcinoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4923
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4923
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