Uropathology

2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Renal Collecting Duct Carcinoma

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4923
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Synonyms

Bellini duct carcinoma

Definition

A highly malignant neoplasm arising from the principal cells of the renal collecting ducts of Bellini.

Clinical Features

  • Incidence

    Collecting duct carcinoma is a rare tumor accounting for 1–2% of renal neoplasms.

  • Age

    It occurs in a wide age range with the median age similar to the other renal carcinoma.

  • Sex

    There is a slight male predominance.

  • Site

    The tumor is centered on the renal medulla.

  • Treatment

    Radical nephrectomy is the standard of care, often with local lymphadenectomy. Since metastases are frequently present at the moment of the diagnosis, the surgical excision is followed by chemotherapy.

  • Outcome

    Frequently the patients are symptomatic, with lymph node involvement and metastases to the lungs, liver, bone, adrenals, and brain at the time of diagnosis.

Macroscopy

They are usually large and infiltrative, whitish, and firm tumors grossly located in the medulla or central parts of the kidney (Fleming and Lewi 1986).

Microscopy

Histologica...
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References and Further Reading

  1. Fleming, S., & Lewi, H. J. (1986). Collecting duct carcinoma of the kidney. Histopathology, 10, 1131–1141.PubMedCrossRefGoogle Scholar
  2. Gupta, R., Billis, A., Shah, R. B., et al. (2012). Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma: Clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationship. The American Journal of Surgical Pathology, 36, 1265–1278.PubMedCrossRefGoogle Scholar
  3. Kobayashi, N., Matsuzaki, O., Shirai, S., et al. (2008). Collecting duct carcinoma of the kidney: An immunohistochemical evaluation of the use of antibodies for differential diagnosis. Human Pathology, 39, 1350–1359.PubMedCrossRefGoogle Scholar
  4. Ohe, C., Smith, S. C., Sirohi, D., et al. (2018). Reappraisal of morphologic differences between renal medullary carcinoma, collecting duct carcinoma, and fumarate hydratase-deficient renal cell carcinoma. The American Journal of Surgical Pathology, 42, 279–292.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly