2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Amyloidosis in the Genitourinary Tract

  • Caterina Fattorini
  • Antonio Lopez-Beltran
  • Maria Rosaria RaspolliniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4779


It is a chronic disease with extracellular amyloid deposits in the genitourinary organs.

Clinical-Pathological Classification

  • Systemic:
    • Primary: Commonly AL type amyloid typically associated with some lymphoproliferative disorders.

    • Secondary: AA type amyloid, linked to various chronic inflammatory diseases (rheumatoid arthritis, Crohn disease, ankylosing spondylitis, myeloma, and familial Mediterranean fever).

  • Localized: Deposition of AL type amyloid of unknown etiology.

  • Familial: Frequently associated with Transthyretin mutations.

Clinical Features

  • Incidence

    The true incidence of systemic and localized amyloidosis in genitourinary organs is not currently available.

  • Age

    5th–6th decade.

  • Sex
    • Systemic: Men are mainly affected by AL amyloidosis, women by AA amyloidosis.

    • Localized: No sex prevalence.

  • Site
    • Systemic: Kidney most commonly affected (Chitale et al. 2007).

    • Localized: Renal pelvis and lower genitourinary tract, particularly urinary bladder but also urethra (Monge et al.

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References and Further Reading

  1. Caballero Martínez, M. C., Gomez, M., Angel Cuesta Alcalá J, et al. (2003). Amyloidosis of the seminal vesicles: Clinical and pathological review of 8 cases diagnosed from surgical specimens. Archivos Españoles de Urología, 56, 431.PubMedGoogle Scholar
  2. Chitale, S., Morsey, M., Peat, D., & Webb, R. (2007). Amyloidosis of lower genitourinary tract: A review. European Urology Supplements, 5, 70–76.Google Scholar
  3. Jain, M., Kumari, N., Chhabra, P., & Gupta, R. (2008). Localized amyloidosis of urinary bladder: A diagnostic dilemma. Indian Journal of Pathology & Microbiology, 51, 247–249.CrossRefGoogle Scholar
  4. Li, Y., Mongan, J., Behr, S. C., et al. (2016). Beyond prostate adenocarcinoma: Expanding the differential diagnosis in prostate pathologic conditions. Radiographics, 36, 1055–1075.CrossRefGoogle Scholar
  5. Monge, M., Chauveau, D., Cordonnier, C., et al. (2011). Localized amyloidosis of the genitourinary tract: Report of 5 new cases and review of the literature. Medicine, 90, 212–222.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Caterina Fattorini
    • 1
  • Antonio Lopez-Beltran
    • 2
    • 3
  • Maria Rosaria Raspollini
    • 1
    Email author
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain