Definition
Oncocytoma is a benign renal cell tumor with mainly solid-nested architecture composed of predominantly large eosinophilic cells packed with mitochondria.
Clinical Features
Oncocytomas are sporadic tumors; cases in association with Birt-Hogg-Dubé (an autosomal dominant disease associated with mutation of the folliculin gene) have been reported.
A group of patients with multiple oncocytic lesions called oncocytosis has been described. Some of these lesions have a hybrid morphology between oncocytoma and chromophobe renal cell carcinoma, suggesting that these neoplasms can be related.
Incidence
They comprise 5% of adult renal epithelial tumors in surgical series.
Age
The peak incidence is in the seventh decade of life.
Sex
Its male-to-female ratio is 2:1.
Site
There is no prevalence of site.
Treatment
Partial or radical nephrectomy, based on the tumor size, is the standard. In selected cases, active surveillance may be an option.
Outcome
Renal oncocytomas are benign neoplasms.
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Brunelli, M., Delahunt, B., Gobbo, S., Tardanico, R., Eccher, A., Bersani, S., Cossu-Rocca, P., Parolini, C., Balzarini, P., Menestrina, F., Cheng, L., Eble, J. N., & Martignoni, G. (2010). Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: A validation study combining metaphase and interphase analyses. American Journal of Clinical Pathology, 133(1), 116–126.
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Trpkov, K., Yilmaz, A., Uzer, D., Dishongh, K. M., Quick, C. M., Bismar, T. A., & Gokden, N. (2010). Renal oncocytoma revisited: A clinicopathological study of 109 cases with emphasis on problematic diagnostic features. Histopathology, 57(6), 893–906.
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Caliò, A., Segala, D., Martignoni, G. (2020). Oncocytoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_3804
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DOI: https://doi.org/10.1007/978-3-030-41894-6_3804
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