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Oncocytoma is a benign renal cell tumor with mainly solid-nested architecture composed of predominantly large eosinophilic cells packed with mitochondria.
Oncocytomas are sporadic tumors; cases in association with Birt-Hogg-Dubé (an autosomal dominant disease associated with mutation of the folliculin gene) have been reported.
They comprise 5% of adult renal epithelial tumors in surgical series.
The peak incidence is in the seventh decade of life.
Its male-to-female ratio is 2:1.
There is no prevalence of site.
Partial or radical nephrectomy, based on the tumor size, is the standard. In selected cases, active surveillance may be an option.
Renal oncocytomas are benign neoplasms.
References and Further Reading
- Brunelli, M., Delahunt, B., Gobbo, S., Tardanico, R., Eccher, A., Bersani, S., Cossu-Rocca, P., Parolini, C., Balzarini, P., Menestrina, F., Cheng, L., Eble, J. N., & Martignoni, G. (2010). Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: A validation study combining metaphase and interphase analyses. American Journal of Clinical Pathology, 133(1), 116–126.CrossRefGoogle Scholar
- Rocca, P. C., Brunelli, M., Gobbo, S., Eccher, A., Bragantini, E., Mina, M. M., Ficarra, V., Zattoni, F., Zamò, A., Pea, M., Scarpa, A., Chilosi, M., Menestrina, F., Bonetti, F., Eble, J. N., & Martignoni, G. (2007). Diagnostic utility of S100A1 expression in renal cell neoplasms: An immunohistochemical and quantitative RT-PCR study. Modern Pathology, 20(7), 722–728.CrossRefGoogle Scholar