2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Nephrogenic Adenoma

  • Maria Rosaria RaspolliniEmail author
  • Antonio Lopez-Beltran
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_3763


Nephrogenic metaplasia


Metaplastic change characterized by small tubules lined by a single layer of cuboidal, flat, or hobnail cells containing eosinophilic secretion with features similar to mesonephric tubules.

Clinical Features

  • Incidence

    This is an uncommon lesion. Most patients have a previous bladder surgery or irritants such calculi or trauma, or kidney transplantation.

  • Age

    Usually seen in adults but rare in children

  • Sex

    Male: female: 3:1

  • Site

    The bladder is the most common (55%) followed by urethra (41%) or ureter (4%).

  • Treatment


  • Outcome

    Benign outcome


These are less than 1 cm polypoid, flat, or papillary lesions. Large size examples have been reported.


The most common microscopic pattern is tubular (Fig. 1). The tubules are small, hollow, and round and sometime elongated. Other patterns are cystic (Fig. 2), papillary, and polypoid and less frequently with a diffuse pattern. Tubules and cysts are lined with cuboidal, hobnail...
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References and Further Reading

  1. McDaniel, A. S., Chinnaiyan, A. M., Siddiqui, J., et al. (2014). Immunohistochemical staining characteristics of nephrogenic adenoma using the PIN-4 cocktail (p63. AMACR, and CK903) and GATA3. The American Journal of Surgical Pathology, 38, 1664–1671.CrossRefGoogle Scholar
  2. Oliva, E., & Young, R. H. (1995). Nephrogenic adenoma of the urinary tract: A review of the microscopic appearance of 80 cases with emphasis on unusual features. Modern Pathology, 8, 722–730.PubMedGoogle Scholar
  3. Tong, G. X., Weeden, E. M., Hamele-Bena, D., et al. (2008). Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: Evidence of related histogenesis? The American Journal of Surgical Pathology, 32, 1380–1387.CrossRefGoogle Scholar
  4. Zhang, G., McDaniel, A. S., Mehra, R., & McKenney, J. K. (2017). Nephrogenic adenoma does not express NKX3.1. Histopathology, 71, 669–671.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Maria Rosaria Raspollini
    • 1
    Email author
  • Antonio Lopez-Beltran
    • 2
    • 3
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology Service, Champalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain