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Adaptor Proteins

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Encyclopedia of Molecular Pharmacology

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Synonyms

Anchoring protein; Docking protein; Scaffold

Definition

Adaptor proteins are multi-domain proteins (Fig. 1) that interact with components of signaling pathways. As a consequence of these interactions, adaptor proteins are able to regulate signaling events within the cell, providing spatiotemporal control and specificity and influencing how a cell responds to a particular stimulus.

Fig. 1
figure 1

Adaptor protein domains. A scheme of the domain structures of some well-characterized adaptor proteins is shown. Descriptions of domain characteristics are in main text except GUK domain, guanylate kinase domain; CHD, calponin homology domain; IQ, isoleucine/glutamine (IQ) domain; GRD, GAP-related domain. For clarity, not all domains contained within these proteins are shown

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References

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Authors and Affiliations

  1. Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA

    Andrew C. Hedman & David B. Sacks

Authors
  1. Andrew C. Hedman
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  2. David B. Sacks
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Corresponding author

Correspondence to David B. Sacks .

Editor information

Editors and Affiliations

  1. Max-Planck-Institut Herz/Lungenforschg., Bad Nauheim, Hessen, Germany

    Stefan Offermanns

  2. Presidential Office, Friedrich-Schiller University Jena, Jena, Thüringen, Germany

    Walter Rosenthal

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Hedman, A.C., Sacks, D.B. (2020). Adaptor Proteins. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-21573-6_265-1

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  • DOI: https://doi.org/10.1007/978-3-030-21573-6_265-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21573-6

  • Online ISBN: 978-3-030-21573-6

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