Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Adaptor Proteins

  • Andrew C. Hedman
  • David B. SacksEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_265-1



Adaptor proteins are multi-domain proteins (Fig. 1) that interact with components of signaling pathways. As a consequence of these interactions, adaptor proteins are able to regulate signaling events within the cell, providing spatiotemporal control and specificity and influencing how a cell responds to a particular stimulus.
This is a preview of subscription content, log in to check access.


  1. Brown MD, Sacks DB (2009) Protein scaffolds in MAP kinase signaling. Cell Signal 21:462–469CrossRefGoogle Scholar
  2. Kumar S, Fajardo JE, Birge RB, Sriram G (2014) Crk at the quarter century mark: perspectives in signaling and cancer. J Cell Biochem 115:819–825CrossRefGoogle Scholar
  3. Langeberg LK, Scott JD (2015) Signalling scaffolds and local organization of cellular behavior. Nat Rev Mol Cell Biol 16:232–244CrossRefGoogle Scholar
  4. Pawson T (2007) Dynamic control of signaling by modular adaptor proteins. Curr Opin Cell Biol 19:112–116CrossRefGoogle Scholar
  5. Sugiura T, Shimizu T, Mijima A, Minakata S, Kato Y (2011) PDZ adaptors: their regulation of epithelial transporters and involvement in human diseases. J Pharm Sci 100:3620–3635CrossRefGoogle Scholar
  6. Wagner MJ, Stacey MM, Liu BA, Pawson T (2013) Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling. Cold Spring Harb Perspect Biol 5:a00897CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Department of Laboratory MedicineNational Institutes of HealthBethesdaUSA