Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Monoamine Oxidases and Their Inhibitors

  • Moussa B. H. YoudimEmail author
  • Keith F. Tipton
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_191-1
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Synonyms

Definition

Monoamine oxidase (amine:oxygen oxidoreductase (deaminating); EC 1.4.3.4; MAO) exists in two forms, named type A and type B. They are responsible for oxidative deamination of primary, secondary, and some tertiary amines, including the neurotransmitters, noradrenaline, dopamine, and serotonin (5-hydroxytryotamine; 5-HT), the hormone adrenaline, and trace amines, such as tyramine, tryptamine, and 2-phenylethylamine. Their nonselective and selective inhibitors are employed for the treatment of depressive illness and Parkinson’s disease.

Reaction Mechanism of Monoamine Oxidase

The role of monoamine oxidase in terminating the action of the aminergic neurotransmitters and dietary amines has been extensively studied; less attention has been paid to the functions of the products formed in the MAO reactions that include aldehyde and acidic metabolites.
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Reading List

  1. Gillman PK (2018) A reassessment of the safety profile of monoamine oxidase inhibitors: elucidating tired old tyramine myths. J Neural Transm (Vienna) 125(11):1707–1717CrossRefGoogle Scholar
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  8. Yeung AWK, Georgieva MG, Atanasov AG, Tzvetkov NT (2019) Monoamine oxidases (MAOs) as privileged molecular targets in neuroscience: research literature analysis. Front Mol Neurosci 12:143CrossRefGoogle Scholar
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  10. Youdim MB, Riederer PF (2007) Monoamine oxidase A and B inhibitors in Parkinson’s disease. Handbook Clin Neurol 84:93–120CrossRefGoogle Scholar
  11. Youdim MB, Edmondson D, Tipton KF (2006) The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci 7(4):295–309CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Eve Topf and NPF Centers of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Faculty of MedicineTechnion-Rappaport FamilyHaifaIsrael
  2. 2.School of Biochemistry and ImmunologyTrinity College, University of DublinDublin 2Ireland