Monoamine Oxidases and Their Inhibitors
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Monoamine oxidase (amine:oxygen oxidoreductase (deaminating); EC 22.214.171.124; MAO) exists in two forms, named type A and type B. They are responsible for oxidative deamination of primary, secondary, and some tertiary amines, including the neurotransmitters, noradrenaline, dopamine, and serotonin (5-hydroxytryotamine; 5-HT), the hormone adrenaline, and trace amines, such as tyramine, tryptamine, and 2-phenylethylamine. Their nonselective and selective inhibitors are employed for the treatment of depressive illness and Parkinson’s disease.
Reaction Mechanism of Monoamine Oxidase
- Tábi T, Vécsei L, Youdim MB, Riederer P, Szökő É (2019) Selegiline: a molecule with innovative potential. J Neural Transm (Vienna). https://doi.org/10.1007/s00702-019-02082-0. [Epub ahead of print]