Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Neurotrophic Factors

Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_101-1



Neurotrophic factors are peptides or protein molecules that support cell survival and cell death in neural and nonneural tissues. In this way, these molecules affect the development, maintenance, and plasticity of the nervous system during the development and in the adulthood (Sampaio et al. 2017).

Herein, the neurotrophic factors are grouped in families, such as the neurotrophin (NT) family, the glial cell-line-derived neurotrophic factor (GDNF) family ligands (GFLs), the neurokine family, fibroblast growth factor (FGF) family, and transforming growth factor-β (TGF-β) family. Moreover, the novel neurotrophic factors, cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF), are also explained in this text. Table 1 summarizes their main components and receptors involved in their mechanism of action and function.
Table 1

Summary of neurotrophic factors’ families and their main components, receptors, and...

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  1. Di Liberto V, Mudo G, Belluardo N (2019) Crosstalk between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCR) in the brain: focus on heteroreceptor complexes and related functional neurotrophic effects. Neuropharmacology 152:67–77.  https://doi.org/10.1016/j.neuropharm.2018.11.018CrossRefPubMedGoogle Scholar
  2. Jones SA, Jenkins BJ (2018) Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nat Rev Immunol 18(12):773–789.  https://doi.org/10.1038/s41577-018-0066-7CrossRefPubMedGoogle Scholar
  3. Li X (2019) The FGF metabolic axis. Front Med.  https://doi.org/10.1007/s11684-019-0711-y
  4. Lindahl M, Danilova T, Palm E, Lindholm P, Voikar V, Hakonen E, Ustinov J, Andressoo JO, Harvey BK, Otonkoski T, Rossi J, Saarma M (2014) MANF is indispensable for the proliferation and survival of pancreatic beta cells. Cell Rep 7(2):366–375.  https://doi.org/10.1016/j.celrep.2014.03.023CrossRefPubMedGoogle Scholar
  5. Lindahl M, Saarma M, Lindholm P (2017) Unconventional neurotrophic factors CDNF and MANF: structure, physiological functions and therapeutic potential. Neurobiol Dis 97(Pt B):90–102.  https://doi.org/10.1016/j.nbd.2016.07.009CrossRefPubMedGoogle Scholar
  6. Moses HL, Roberts AB, Derynck R (2016) The discovery and early days of TGF-beta: a historical perspective. Cold Spring Harb Perspect Biol 8(7).  https://doi.org/10.1101/cshperspect.a021865
  7. Nathanson NM (2012) Regulation of neurokine receptor signaling and trafficking. Neurochem Int 61(6):874–878.  https://doi.org/10.1016/j.neuint.2012.01.018CrossRefPubMedPubMedCentralGoogle Scholar
  8. Pasquin S, Sharma M, Gauchat JF (2015) Ciliary neurotrophic factor (CNTF): new facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies. Cytokine Growth Factor Rev 26(5):507–515.  https://doi.org/10.1016/j.cytogfr.2015.07.007CrossRefPubMedGoogle Scholar
  9. Poyhonen S, Er S, Domanskyi A, Airavaara M (2019) Effects of neurotrophic factors in glial cells in the central nervous system: expression and properties in neurodegeneration and injury. Front Physiol 10:486.  https://doi.org/10.3389/fphys.2019.00486CrossRefPubMedPubMedCentralGoogle Scholar
  10. Rayego-Mateos S, Rodrigues-Diez R, Morgado-Pascual JL, Valentijn F, Valdivielso JM, Goldschmeding R, Ruiz-Ortega M (2018) Role of epidermal growth factor receptor (EGFR) and its ligands in kidney inflammation and damage. Mediat Inflamm 2018:8739473.  https://doi.org/10.1155/2018/8739473CrossRefGoogle Scholar
  11. Sampaio TB, Savall AS, Gutierrez MEZ, Pinton S (2017) Neurotrophic factors in Alzheimer’s and Parkinson’s diseases: implications for pathogenesis and therapy. Neural Regen Res 12(4):549–557.  https://doi.org/10.4103/1673-5374.205084CrossRefPubMedPubMedCentralGoogle Scholar
  12. Saragovi HU, Galan A, Levin LA (2019) Neuroprotection: pro-survival and anti-neurotoxic mechanisms as therapeutic strategies in neurodegeneration. Front Cell Neurosci 13:231.  https://doi.org/10.3389/fncel.2019.00231CrossRefPubMedPubMedCentralGoogle Scholar

Authors and Affiliations

  1. 1.Postgraduate Program in PharmacologyFederal University of Santa Maria (UFSM)Santa MariaBrazil
  2. 2.Postgraduate Program in BiochemistryFederal University of Pampa (UNIPAMPA)UruguaianaBrazil