Encyclopedia of Molecular Pharmacology

Living Edition
| Editors: Stefan Offermanns, Walter Rosenthal

Neurotrophic Factors

  • Tuane Bazanella Sampaio
  • Simone PintonEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-030-21573-6_101-1
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Synonyms

Definition

Neurotrophic factors are peptides or protein molecules that support cell survival and cell death in neural and nonneural tissues. In this way, these molecules affect the development, maintenance, and plasticity of the nervous system during the development and in the adulthood (Sampaio et al. 2017).

Herein, the neurotrophic factors are grouped in families, such as the neurotrophin (NT) family, the glial cell-line-derived neurotrophic factor (GDNF) family ligands (GFLs), the neurokine family, fibroblast growth factor (FGF) family, and transforming growth factor-β (TGF-β) family. Moreover, the novel neurotrophic factors, cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF), are also explained in this text. Table 1 summarizes their main components and receptors involved in their mechanism of action and function.
Table 1

Summary of neurotrophic factors’ families and their main components, receptors, and...

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg New York 2020

Authors and Affiliations

  1. 1.Postgraduate Program in PharmacologyFederal University of Santa Maria (UFSM)Santa MariaBrazil
  2. 2.Postgraduate Program in BiochemistryFederal University of Pampa (UNIPAMPA)UruguaianaBrazil