Encyclopedia of Mathematics Education

2020 Edition
| Editors: Stephen Lerman

22q11.2 Deletion Syndrome, Special Needs, and Mathematics Learning

  • Sophie BrigstockeEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-15789-0_175

Characteristics

Chromosome 22q11.2 deletion syndrome (22q) is the most common genetic deletion syndrome with an estimated prevalence of between one in 3000 and 6000 births (e.g., Kobrynski and Sullivan 2007). It has only been detectable with 100% accuracy since 1992 using techniques such as the FISH test (fluorescence in situ hybridization). Prior to identification of a single associated deletion, the syndrome had been given a number of different labels according to the primary medical condition, for example, velocardiofacial syndrome, DiGeorge syndrome, Cayler syndrome, Shprintzen syndrome, and Catch 22.

The majority of individuals with 22q experience some degree of learning difficulty and generally show a marked imbalance in performance across different subtests within IQ batteries. Verbal IQ scores are usually significantly higher than performance IQ scores (e.g., Moss et al. 1999; Wang et al. 2007). The majority of children will receive some form of support at school although some...

Keywords

Genetic disorder Mathematics difficulties Cognitive impairment 
This is a preview of subscription content, log in to check access.

References

  1. De Smedt B, Swillen A, Devriendt K, Fryns J, Verschaffel L, Ghesquiere P (2006) Mathematical disabilities in young primary school children with velo-cardio-facial syndrome. Genet Couns 17:259–280Google Scholar
  2. De Smedt B, Devriendt K, Fryns JP, Vogels A, Gewillig M, Swillen A (2007a) Intellectual abilities in a large sample of children with velo-cardio-facial syndrome: an update. J Intellect Disabil Res 51:666–670CrossRefGoogle Scholar
  3. De Smedt B, Swillen A, Devriendt K, Fryns J, Verschaffel L, Ghesquiere P (2007b) Mathematical disabilities in children with velo-cardio-facial syndrome. Neuropsychologia 45:885–895CrossRefGoogle Scholar
  4. Kobrynski L, Sullivan K (2007) Velocardiofacial syndrome, DiGeorge syndrome: the chromosome 22q11.2 deletion syndromes. Lancet 370(9596):1443–1452CrossRefGoogle Scholar
  5. Moss E, Batshaw M, Solot C, Gerdes M, McDonald-McGinn D, Driscoll D, Emanuel B, Zackai E, Wang P (1999) Psychoeducational profile of the 22q11.2 microdeletion: a complex pattern. J Pediatr 134(2):193–198CrossRefGoogle Scholar
  6. Venneri A, Cornoldi C, Garuti M (2003) Arithmetic difficulties in children with visuospatial learning disability (VLD). Child Neuropsychol 9(3):175–183CrossRefGoogle Scholar
  7. Wang P, Woodin F, Kreps-Falk R, Moss E (2007) Research on behavioral phenotypes: velocardiofacial syndrome (deletion 22q11.2). Dev Med Child Neurol 42:422–427CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of PsychologyUniversity of YorkYorkUK