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Acanthamoeba, Naegleria, and Balamuthia in Transplant Patients: An Emerging Threat

  • Yoram A. PuiusEmail author
  • Margaret L. Aldrich
  • Jennifer R. Cope
Living reference work entry
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Abstract

Free-living amoebae (FLA) are ubiquitous in the environment. Although they rarely cause infection in humans, when they do so, the infection is often severe and diagnosed late. The three most clinically relevant genera of FLA are Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris. An increasing body of literature points to these organisms as potential disease-causing agents in immunocompromised and transplant patients, particularly with regard to donor-derived infections. This chapter will review the salient features, diagnostic modalities, and therapeutic recommendations of these infections in transplant patients.

Keywords

Naegleria fowleri Acanthamoeba Balamuthia mandirllaris Primary amebic meningoencephalitis Granulomatous amebic encephealitis Donor-derived infection 

Notes

Disclaimer

The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Yoram A. Puius
    • 1
    Email author
  • Margaret L. Aldrich
    • 2
  • Jennifer R. Cope
    • 3
  1. 1.Division of Infectious Diseases, Department of MedicineMontefiore Medical Center and Albert Einstein College of MedicineBronxUSA
  2. 2.Division of Pediatric Infectious Diseases, Department of PediatricsMontefiore Medical Center and Albert Einstein College of MedicineBronxUSA
  3. 3.Waterborne Disease Prevention BranchNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and PreventionAtlantaUSA

Section editors and affiliations

  • Camille Nelson Kotton
    • 1
  1. 1.Infectious Diseases DivisionHarvard University Medical SchoolBostonUSA

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