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Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients: Prevention, Diagnosis, and Treatment

  • Jose F. CamargoEmail author
Living reference work entry
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Abstract

Human herpesvirus 5, better known as cytomegalovirus (CMV), infects 50–90% of the adult population worldwide and is the most common opportunistic infection in allogeneic hematopoietic stem cell transplant (HSCT) recipients, causing significant morbidity and mortality [1–6]. Without prophylaxis, CMV reactivation occurs in up to 70–80% of CMV-seropositive individuals [6–9]. This chapter will review the current understanding of CMV infection in HSCT recipients focusing on emerging concepts and updated recommendations for CMV prevention, diagnosis, and management.

Keywords

Cytomegalovirus Hematopoietic cell transplant Prophylaxis Pre-emptive therapy Resistance 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of Infectious DiseasesUniversity of Miami Miller School of MedicineMiamiUSA

Section editors and affiliations

  • Michele I. Morris
    • 1
  1. 1.Division of Infectious DiseasesUniversity of Miami Miller School of MedicineMiamiUSA

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