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Cytotoxic T cells and NK cells kill target cells by mobilizing secretory granules containing perforin and other agents, such as granzyme, to the cellular membrane and releasing the contents into the intercellular space at the immunologic synapse. Toward the final steps of the degranulation pathway, lytic granules are tethered to the plasma membrane through interactions between Rab27a and Munc13-4. Syntaxin-11 and Munc18-2 then work cooperatively to enable lytic granule secretion. During degranulation, syntaxin-11 localizes to the plasma membrane at immunologic synapses to promote docking of lytic granules. This initial syntaxin-11 plasma membrane localization requires Munc18-2 (Dieckmann et al. 2015). In human cytotoxic T cells, syntaxin-11 then complexes with SNAP23 and...
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