Rac2 which is expressed in cells of hematopoietic origin is a regulatory element that constitutes the predominant NADPH oxidase complex in leukocytes. Thus, it regulates superoxide production, direct migration in neutrophils and play distinct roles in actin organization, cell survival, and proliferation. Its deficiency leads to an immunodeficiency clinically similar to Chronic Granulomatous Diseases. Interestingly, it was shown that RAC2 is involved also in T and B cell immunity.
Rho GTPases, members of the Ras superfamily of GTPases, regulate a wide variety of cellular activities including actin cytoskeleton reorganization, chemotaxis, gene transcription, cell growth, and development. These proteins are divided into six families based on sequence homology, protein domains, and function. Of them, Rac (Ras-related C3 botulinum toxin) proteins composed of three different isoforms, namely, Rac1, Rac2, and Rac3. Rac1 and...
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