NF-kappa B-Inducing Kinase (NIK)
One of the many kinases which transduce signals from the cell membrane to the nucleus in select cells and processes.
Using TRAF2 to study proteins involved in NFKB pathways, Malinin et al. cloned NK-kappa B inducing kinase (NIK) (Malinin et al. 1997). NIK, which is a multifunctional, is officially known as mitogen-activated protein-kinase-kinase-kinase 14 (MAP 3K14) participates in the activation of NF-kB by TNF, CD95, IL1, but not TGF beta, which uses an NIK-independent mechanisms. (Sakurai et al. 1998) The “canonical” NF-kB pathway drives many inflammatory processes; however, the “noncanonical” pathway is also a crucial activation cascade (Zarnegar et al. 2008). The NIK-dependent pathway is “noncanonical,” in that it does not require the NF-kappa essential modulator (NEMO, inhibitor of nuclear factor kappa-B kinase subunit gamma) (Gray et al. 2014)....
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