Encyclopedia of Medical Immunology

Living Edition
| Editors: Ian MacKay, Noel R. Rose

NF-kappa B-Inducing Kinase (NIK)

  • Robert P. NelsonEmail author
Living reference work entry
First Online:
DOI: https://doi.org/10.1007/978-1-4614-9209-2_110-1
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Synonyms

HGNC #25391; Mitogen-activated protein kinase kinase kinase 14 (MAP3K14); OMIM # 604655

Definition

One of the many kinases which transduce signals from the cell membrane to the nucleus in select cells and processes.

Introduction/Background

Using TRAF2 to study proteins involved in NFKB pathways, Malinin et al. cloned NK-kappa B inducing kinase (NIK) (Malinin et al. 1997). NIK, which is a multifunctional, is officially known as mitogen-activated protein-kinase-kinase-kinase 14 (MAP 3K14) participates in the activation of NF-kB by TNF, CD95, IL1, but not TGF beta, which uses an NIK-independent mechanisms. (Sakurai et al. 1998) The “canonical” NF-kB pathway drives many inflammatory processes; however, the “noncanonical” pathway is also a crucial activation cascade (Zarnegar et al. 2008). The NIK-dependent pathway is “noncanonical,” in that it does not require the NF-kappa essential modulator (NEMO, inhibitor of nuclear factor kappa-B kinase subunit gamma) (Gray et al. 2014)....

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References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Professor of Medicine and PediatricsIndiana University School of Medicine, Immunohematology and TransplantationIndianapolisUSA

Section editors and affiliations

  • M Teresa de la Morena
    • 1
  • Robert P. Nelson
    • 2
  1. 1.University of Washington and Seattle Children's HospitalSeattleUSA
  2. 2.Hematology and OncologyIndiana UniversityIndianapolisUSA