NF-kappa B-Inducing Kinase (NIK)
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Synonyms
Definition
One of the many kinases which transduce signals from the cell membrane to the nucleus in select cells and processes.
Introduction/Background
Using TRAF2 to study proteins involved in NFKB pathways, Malinin et al. cloned NK-kappa B inducing kinase (NIK) (Malinin et al. 1997). NIK, which is a multifunctional, is officially known as mitogen-activated protein-kinase-kinase-kinase 14 (MAP 3K14) participates in the activation of NF-kB by TNF, CD95, IL1, but not TGF beta, which uses an NIK-independent mechanisms. (Sakurai et al. 1998) The “canonical” NF-kB pathway drives many inflammatory processes; however, the “noncanonical” pathway is also a crucial activation cascade (Zarnegar et al. 2008). The NIK-dependent pathway is “noncanonical,” in that it does not require the NF-kappa essential modulator (NEMO, inhibitor of nuclear factor kappa-B kinase subunit gamma) (Gray et al. 2014)....
References
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