Encyclopedia of Medical Immunology

Living Edition
| Editors: Ian MacKay, Noel R. Rose

Dedicator of Cytokinesis 2: DOCK2 Deficiency

  • R. P. NelsonJrEmail author
Living reference work entry
First Online:
DOI: https://doi.org/10.1007/978-1-4614-9209-2_104-1
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Synonyms

DOCK2, OMIM # 603122; HGNC #2988. Dedicator of cytokinesis 2

Introduction/Background

The Rho families GTPases regulate membrane polarization and cytoskeletal dynamics fundamental to cell migration. The protein families Caenorhabditis elegans CED-5 and Drosophila melanogaster Myoblast City (CDM), associated with the gene product of avian sarcoma virus CT10 (CRK), function to extend cell membranes (Nishihara et al. 1999). A mammalian homologue to the CDM family, dedicator of cytokinesis 2 (DOCK2) binds and activates Rac family small GTPase 1 (Rac1) and associates with engulfment and cell motility (ELMO1) through its Src-homology 3 (SH3) domain (Sanui et al. 2003). This signaling matrix regulates cytoskeletal reorganization through Ras-related C3 botulinum toxin substrate (Rac) that generates actin-rich lamelli-podial protrusions that drive movement. DOCK2 is expressed predominantly in peripheral blood cells, less in the spleen and thymus, and enables T- and B-lymphocytes to...

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References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Professor of Medicine and PediatricsIndiana University School of Medicine Immunohematology and TransplantationIndianapolisUSA
  2. 2.Riley Hospital for Children at Indiana University HealthIndianapolisUSA

Section editors and affiliations

  • M Teresa de la Morena
    • 1
  • Robert P. Nelson
    • 2
  1. 1.University of Washington and Seattle Children's HospitalSeattleUSA
  2. 2.Hematology and OncologyIndiana UniversityIndianapolisUSA