Dedicator of Cytokinesis 2: DOCK2 Deficiency
The Rho families GTPases regulate membrane polarization and cytoskeletal dynamics fundamental to cell migration. The protein families Caenorhabditis elegans CED-5 and Drosophila melanogaster Myoblast City (CDM), associated with the gene product of avian sarcoma virus CT10 (CRK), function to extend cell membranes (Nishihara et al. 1999). A mammalian homologue to the CDM family, dedicator of cytokinesis 2 (DOCK2) binds and activates Rac family small GTPase 1 (Rac1) and associates with engulfment and cell motility (ELMO1) through its Src-homology 3 (SH3) domain (Sanui et al. 2003). This signaling matrix regulates cytoskeletal reorganization through Ras-related C3 botulinum toxin substrate (Rac) that generates actin-rich lamelli-podial protrusions that drive movement. DOCK2 is expressed predominantly in peripheral blood cells, less in the spleen and thymus, and enables T- and B-lymphocytes to...