Encyclopedia of Computational Neuroscience

Living Edition
| Editors: Dieter Jaeger, Ranu Jung

Action Potential Back-Propagation

  • Sonia GaspariniEmail author
  • Michele Migliore
Living reference work entry

Latest version View entry history

DOI: https://doi.org/10.1007/978-1-4614-7320-6_123-5

Synonyms

Definition

Action potential (AP) back-propagation, as opposed to forward-propagation along the axon, consists of the conduction of the axonally initiated AP along neuronal dendrites, in the form of a depolarization sustained by both active and passive mechanisms. The amplitude of the depolarization generally decreases along the dendrites with increasing distance from the soma; the degree of attenuation is highly variable and depends on the neuronal type.

Detailed Description

Simultaneous recordings from dendrites, soma, and axon have shown that action potentials are generally initiated in the axon initial segment, the region with the lowest threshold for AP initiation (Stuart et al. 1997; Spruston et al. 2016). In addition to canonical forward-propagation along the axon to the presynaptic terminals, APs rapidly invade the soma and propagate back into the dendrites, where voltage-dependent channels actively...
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Notes

Acknowledgments

This work was supported by the National Institutes of Health (grant NIH R01 MH115832 under the CRCNS program to SG) and by the Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) to MM.

References

  1. Boivin JR, Nedivi E (2018) Functional implications of inhibitory synapse placement on signal processing in pyramidal neuron dendrites. Curr Opin Neurobiol 51:16–22CrossRefGoogle Scholar
  2. Deo C, Lavis LD (2018) Synthetic and genetically encoded fluorescent neural activity indicators. Curr Opin Neurobiol 50:101–108CrossRefGoogle Scholar
  3. Gasparini S (2011) Distance- and activity-dependent modulation of spike back-propagation in layer V pyramidal neurons of the medial entorhinal cortex. J Neurophysiol 105:1372–1379CrossRefGoogle Scholar
  4. Gurkiewicz M, Korngreen A (2006) Recording, analysis, and function of dendritic voltage-gated channels. Pflugers Arch 453:283–292CrossRefGoogle Scholar
  5. Johnston D, Magee JC, Colbert CM, Cristie BR (1996) Active properties of neuronal dendrites. Annu Rev Neurosci 19:165–186CrossRefGoogle Scholar
  6. Johnston D, Hoffman DA, Colbert CM, Magee JC (1999) Regulation of back-propagating action potentials in hippocampal neurons. Curr Opin Neurobiol 9:288–292CrossRefGoogle Scholar
  7. Johnston D, Hoffman DA, Magee JC, Poolos NP, Watanabe S, Colbert CM, Migliore M (2000) Dendritic potassium channels in hippocampal pyramidal neurons. J Physiol 525(Pt 1):75–81CrossRefGoogle Scholar
  8. Ludwig M, Pittman QJ (2003) Talking back: dendritic neurotransmitter release. Trends Neurosci 26:255–261CrossRefGoogle Scholar
  9. Magee JC (2016) Voltage-gated ion channels in dendrites. In: Stuart G, Spruston N, Haüsser M (eds) Dendrites, 3rd edn. Oxford University Press, New York, pp 259–284CrossRefGoogle Scholar
  10. Magee JC, Johnston D (2005) Plasticity of dendritic function. Curr Opin Neurobiol 15:334–342CrossRefGoogle Scholar
  11. Maheux J, Froemke RC, Sjöström PJ (2016) Functional plasticity at dendritic synapses. In: Stuart G, Spruston N, Haüsser M (eds) Dendrites, 3rd edn. Oxford University Press, New York, pp 505–555CrossRefGoogle Scholar
  12. Migliore M, Shepherd GM (2002) Emerging rules for the distributions of active dendritic conductances. Nat Rev Neurosci 3:362–370CrossRefGoogle Scholar
  13. Migliore M, Shepherd GM (2005) Opinion: an integrated approach to classifying neuronal phenotypes. Nat Rev Neurosci 6:810–818CrossRefGoogle Scholar
  14. Migliore M, Hoffman DA, Magee JC, Johnston D (1999) Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. J Comput Neurosci 7:5–15CrossRefGoogle Scholar
  15. Palmer L, Murayama M, Larkum M (2016) Dendritic integration in vitro. In: Stuart G, Spruston N, Haüsser M (eds) Dendrites, 3rd edn. Oxford University Press, New York, pp 399–427CrossRefGoogle Scholar
  16. Roome CJ, Kuhn B (2018) Simultaneous dendritic voltage and calcium imaging and somatic recording from Purkinje neurons in awake mice. Nat Commun 23:3388CrossRefGoogle Scholar
  17. Scanziani M, Häusser M (2009) Electrophysiology in the age of light. Nature 461:930–939CrossRefGoogle Scholar
  18. Schaefer AT, Larkum ME, Sakmann B, Roth A (2003) Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. J Neurophysiol 89:3143–3154CrossRefGoogle Scholar
  19. Spruston N (2008) Pyramidal neurons: dendritic structure and synaptic integration. Nat Rev Neurosci 9:206–221CrossRefGoogle Scholar
  20. Spruston N, Stuart G, Häusser M (2016) Principles of dendritic integration. In: Stuart G, Spruston N, Haüsser M (eds) Dendrites, 3rd edn. Oxford University Press, New York, pp 351–398CrossRefGoogle Scholar
  21. Stuart G, Spruston N, Sakmann B, Häusser M (1997) Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci 20: 125–131CrossRefGoogle Scholar
  22. Vetter P, Roth A, Häusser M (2001) Propagation of action potentials in dendrites depends on dendritic morphology. J Neurophysiol 85:926–937CrossRefGoogle Scholar
  23. Watanabe S, Hoffman DA, Migliore M, Johnston D (2002) Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 99: 8366–8371CrossRefGoogle Scholar
  24. Waters J, Schaefer A, Sakmann B (2005) Backpropagating action potentials in neurones: measurement, mechanisms and potential functions. Prog Biophys Mol Biol 87:145–170CrossRefGoogle Scholar

Further Reading

  1. Davie JT, Kole MH, Letzkus JJ, Rancz EA, Spruston N, Stuart GJ, Häusser M (2006) Dendritic patch-clamp recording. Nat Protoc 1:1235–1247CrossRefGoogle Scholar
  2. Spruston N, Häusser M, Stuart G (2013) Information processing in dendrites and spines. In: Squire LR et al (eds) Fundamental neuroscience, 4th edn. Elsevier, Amsterdam, pp 231–260CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Neuroscience CenterLouisiana State University Health Sciences Center-New OrleansNew OrleansUSA
  2. 2.National Research CouncilInstitute of BiophysicsPalermoItaly

Section editors and affiliations

  • Volker Steuber
    • 1
  1. 1.Centre for Computer Science and Informatics ResearchUniversity of HertfordshireHatfieldUK