Encyclopedia of Autism Spectrum Disorders

Living Edition
| Editors: Fred R. Volkmar

Risperdal ™ (Risperidone)

  • Elizabeth A. DeLuciaEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6435-8_102093-1



Risperdal ™ (generic name risperidone) is an atypical antipsychotic medication. It has been approved by the US Food and Drug Administration (FDA) to treat schizophrenia, bipolar disorder, and irritability associated with ASD. Risperdal ™ is a dopamine and serotonin antagonist. Dopamine is a neurotransmitter related to reward pathways in the brain, while serotonin is involved in mood regulation. Risperdal ™ works by blocking postsynaptic dopamine and serotonin receptors. Specifically, Risperdal ™ binds to D2 dopamine receptors and 5-HT2A serotonin receptors, decreasing the amount of dopaminergic and serotonergic activity in the brain.

In 2006, Risperdal ™ was the first medication approved by the FDA for symptoms associated with ASD in children and adolescents. (The FDA subsequently approved aripiprazole, another atypical antipsychotic, for treatment of symptoms associated with ASD in 2009.) Risperdal ™ treats irritability associated with ASD and has been...

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References and Reading

  1. LeClerc, S., & Easley, D. (2015). Pharmacological Therapies for Autism Spectrum Disorder: A Review. Pharmacy and Therapeutics, 40(6), 389–397.PubMedPubMedCentralGoogle Scholar
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  3. McCracken, J. T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., … & McDougle, C. J. (2002). Risperidone in children with autism and serious behavioral problems. New England Journal of Medicine, 347(5), 314–321.CrossRefGoogle Scholar
  4. McDougle, C. J., Holmes, J. P., Carlson, D. C., Pelton, G. H., Cohen, D. J., & Price, L. H. (1998). A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Archives of General Psychiatry, 55(7), 633–641.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Yale Child Study CenterNew HavenUSA