Inositol is an abundant sugar responsible for important cellular transduction pathways involving hormones, neurotransmitters, and growth factors (Parthasarathy et al.). Among the nine inositol isomers, the myo-inositol has the greatest biological activity and serves to synthesize cell membrane inositol phospholipids (Parthasarathy et al.). In the brain, myo-inositol links several extracellular signaling pathways activating phospholipase C and increasing cytosolic calcium from the endoplasmic reticulum (Parthasarathy et al.). The resulting calcium surge activates many enzymes and receptors controlling essential physiological and neurological functions (Parthasarathy et al.).
As a result, the inositol pathway remains an attractive pharmacological target towards the treatment and management of many psychiatric disorders. Several clinical studies have demonstrated a correlation between decreased myo-inositol levels and the severity...
References and Reading
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