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Lipid Mediators and Modulators of Neural Function: Lysophosphatidate and Lysolipids

  • D. N. Brindley
  • A. U. Bräuer
Reference work entry

Abstract

There is an increasing body of knowledge that demonstrates important roles for lysophosphatidate (LPA) and other biologically active lipids in controlling cell signaling including regulation of cell division, death, and movement. These processes are important aspects of brain development, repair, and the normal functioning of the brain. We now know that LPA activates at least five G-protein coupled receptors. The signal that cells receive depends upon the G-proteins that couple to the receptors and the relative expression of various receptors on different cells. Additionally, the role of LPA in controlling signal transduction is regulated by enzymes that are responsible for its turnover and also for controlling signaling events downstream of receptor activation.

Keywords

Experimental Autoimmune Encephalomyelitis PAP1 Activity Bioactive Lipid Secretory Phospholipase Choroid Plexus Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

ATX

autotaxin or lysophospholipase D

CNS

central nervous system

C1P

ceramide 1-phosphate

C20:4

arachidonic acid

DAG

diacylglycerol

EAE

experimental autoimmune encephalomyelitis

EPMR

epilepsy with mental retardation

LCAT

lecithin:cholesterol acyltransferase, LPA, lysophosphatidate

LPC

lysophosphatidylcholine

MAG

monoacylglycerol

MS

multiple sclerosis

PA

phosphatidate

PLD

phospholipase D

PRG

plasticity related genes

S1P

sphingosine 1-phosphate

2-AG

sn-2-monoarachidonoylglycerol

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • D. N. Brindley
  • A. U. Bräuer

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