Abbreviations and Acronyms
- APCI :
-
Atmospheric pressure chemical ionization
- EI :
-
Electron ionization
- ESI :
-
Electrospray ionization
- FT-ICR :
-
Fourier-transform ion cyclotron resonance
- GC :
-
Gas chromatography
- GP :
-
Diacylglycerophospholipid
- HPLC :
-
High-performance liquid chromatography
- IMS :
-
Ion mobility spectrometry
- IT :
-
Ion trap
- LC :
-
Liquid chromatography
- MALDI :
-
Matrix-assisted laser desorption/ionization
- MS :
-
Mass spectrometry
- MS/MS :
-
Tandem mass spectrometry
- NAFLD :
-
Nonalcoholic fatty liver disease
- PC :
-
Phosphatidylcholine
- PE :
-
Phosphatidylethanolamine
- PI :
-
Phosphatidylinositol
- PL :
-
Phospholipid
- TLC :
-
Thin-layer chromatography
- TOF :
-
Time-of-flight
Introduction
Mass spectrometry (MS) is unequivocally one of the most powerful and contemporary methods of (phospho)lipid analysis (Yang and Han 2016). The extreme sensitivity of MS, its considerable mass accuracy, and high mass resolution (dependent on the used mass spectrometer and the quality of its mass analyzer) enable the detailed...
References
Bandu R, Mok HJ, Kim KP. Phospholipids as cancer biomarkers: mass spectrometry-based analysis. Mass Spectrom Rev. 2018;37:107–38.
Bielawska K, Dziakowska I, Roszkowska-Jakimiec W. Chromatographic determination of fatty acids in biological material. Toxicol Mech Methods. 2010;20:526–37.
Brügger B. Lipidomics: analysis of the lipid composition of cells and subcellular organelles by electrospray ionization mass spectrometry. Annu Rev Biochem. 2014;83:79–98.
Bruins AP. Mechanistic aspects of electrospray ionization. J Chromatogr A. 1998;794:345–57.
Byrdwell WC. Atmospheric pressure chemical ionization mass spectrometry for analysis of lipids. Lipids. 2001;36:327–46.
Domingues MR, Reis A, Domingues P. Mass spectrometry analysis of oxidized phospholipids. Chem Phys Lipids. 2008;156:1–12.
Eibisch M, Fuchs B, Schiller J, Süß R, Teuber K. Analysis of phospholipid mixtures from biological tissues by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS): a laboratory experiment. J Chem Educat. 2011;88:503–7.
Ellis SR, Brown SH, In Het Panhuis M, Blanksby SJ, Mitchell TW. Surface analysis of lipids by mass spectrometry: more than just imaging. Prog Lipid Res. 2013;52:329–53.
Engel KM, Schiller J. A comparison of PC oxidation products as detected by MALDI-TOF and ESI-IT mass spectrometry. Chem Phys Lipids. 2017;203:33–45.
Engel KM, Griesinger H, Schulz M, Schiller J. Normal-phase versus reversed-phase thin-layer chromatography (TLC) to monitor oxidized phosphatidylcholines by TLC/mass spectrometry. Rapid Commun Mass Spectrom. 2019;33:60–5.
Fuchs B, Schiller J. Mass spectrometry of biological molecules. In: Encyclopedia of analytical chemistry. John Wiley & Sons Ltd., Chichester; 2016.
Fuchs B, Süss R, Schiller J. An update of MALDI-TOF mass spectrometry in lipid research. Prog Lipid Res. 2010;49:450–75.
Fuchs B, Süss R, Teuber K, Eibisch M, Schiller J. Lipid analysis by thin-layer chromatography – a review of the current state. J Chromatogr A. 2011;1218:2754–74.
Furey A, Moriarty M, Bane V, Kinsella B, Lehane M. Ion suppression; a critical review on causes, evaluation, prevention and applications. Talanta. 2013;115:104–22.
Giles C, Takechi R, Lam V, Dhaliwal SS, Mamo JCL. Contemporary lipidomic analytics: opportunities and pitfalls. Prog Lipid Res. 2018;71:86–100.
Gode D, Volmer, DA. Lipid imaging by mass spectrometry – a review. Analyst. 2013;138:1289–315.
Griesinger H, Fuchs B, Süß R, Matheis K, Schulz M, Schiller J. Stationary phase thickness determines the quality of thin-layer chromatography/matrix-assisted laser desorption and ionization mass spectra of lipids. Anal Biochem. 2014;451:45–7.
Groessl M, Graf S, Knochenmuss R. High resolution ion mobility-mass spectrometry for separation and identification of isomeric lipids. Analyst. 2015;140:6904–11.
Gros M, Borros S, Amabilino DB, Veciana J, Folch I. Characterization of the vulcanization products of squalene by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: model studies on the vulcanization of natural rubber. J Mass Spectrom. 2001;36:294–300.
Gross JH. Mass spectrometry – a textbook. 2nd ed. Heidelberg: Springer; 2011.
Hofmann T, Schmidt C. Instrument response of phosphatidylglycerol lipids with varying fatty acyl chain length in nano-ESI shotgun experiments. Chem Phys Lipids. 2019;223:104782.
Hsu FF, Lodhi IJ, Turk J, Semenkovich CF. Structural distinction of diacyl-, alkylacyl, and alk-1-enylacyl glycerophosphocholines as [M – 15]− ions by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom. 2014;25:1412–20.
Hyötyläinen T, Orešič M. Systems biology strategies to study lipidomes in health and disease. Prog Lipid Res. 2014;55:43–60.
Jaskolla TW, Karas M. Compelling evidence for Lucky Survivor and gas phase protonation: the unified MALDI analyte protonation mechanism. J Am Soc Mass Spectrom. 2011;22:976–88.
Kayganich KA, Murphy RC. Fast atom bombardment tandem mass spectrometric identification of diacyl, alkylacyl, and alk-1-enylacyl molecular species of glycerophosphoethanolamine in human polymorphonuclear leukocytes. Anal Chem. 1992;64:2965–71.
Kilár A, Dörnyei Á, Kocsis B. Structural characterization of bacterial lipopolysaccharides with mass spectrometry and on- and off-line separation techniques. Mass Spectrom Rev. 2013;32:90–117.
Koivusalo M, Haimi P, Heikinheimo L, Kostiainen R, Somerharju P. Quantitative determination of phospholipid compositions by ESI-MS: effects of acyl chain length, unsaturation, and lipid concentration on instrument response. J Lipid Res. 2001;42:663–72.
Lam SM, Shui G. Lipidomics as a principal tool for advancing biomedical research. J Genet Genomics. 2013;40:375–90.
Li Z, Agellon LB, Allen TM, Umeda M, Jewell L, Mason A, Vance DE. The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab. 2006;3:321–31.
Li X, He Q, Hou H, Zhang S, Zhang X, Zhang Y, Wang X, Han L, Liu K. Targeted lipidomics profiling of marine phospholipids from different resources by UPLC-Q-Exactive Orbitrap/MS approach. J Chromatogr B. 2018;1096:107–12.
Liebisch G, Vizcaíno JA, Köfeler H, Trötzmüller M, Griffiths WJ, Schmitz G, Spener F, Wakelam MJ. Shorthand notation for lipid structures derived from mass spectrometry. J Lipid Res. 2013;54:1523–30.
Liu S, Sjövall J, Griffiths WJ. Neurosteroids in rat brain: extraction, isolation, and analysis by nanoscale liquid chromatography-electrospray mass spectrometry. Anal Chem. 2003;75:5835–46.
Nimptsch A, Fuchs B, Süß R, Zschörnig K, Jakop U, Göritz F, Schiller J, Müller K. A simple method to identify ether lipids in spermatozoa samples by MALDI-TOF mass spectrometry. Anal Bioanal Chem. 2013;405:6675–82.
Pham HT, Maccarone AT, Thomas MC, Campbell JL, Mitchell TW, Blanksby SJ. Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards “top-down” lipidomics. Analyst. 2014;139:204–14.
Pulfer M, Murphy RC. Electrospray mass spectrometry of phospholipids. Mass Spectrom Rev. 2003;22:332–64.
Sales S, Knittelfelder O, Shevchenko A. Lipidomics of human blood plasma by high-resolution shotgun mass spectrometry. Methods Mol Biol. 2017;1619:203–12.
Sethi S, Brietzke E. Recent advances in lipidomics: analytical and clinical perspectives. Prostaglandins Other Lipid Mediat. 2017;128–129:8–16.
Tuzimski T, Sherma J. Encyclopedia of lipidomics. Thin-layer chromatography and mass spectrometry for the analysis of lipids. Dordrecht: Springer; 2016.
Vasquez AM, Mouchlis VD, Dennis EA. Review of four major distinct types of human phospholipase A2. Adv Biol Regul. 2018;67:212–8.
Wang C, Wang M, Han X. Applications of mass spectrometry for cellular lipid analysis. Mol Biosyst. 2015;11:698–713.
Wang M, Wang C, Han RH, Han X. Novel advances in shotgun lipidomics for biology and medicine. Prog Lipid Res. 2016;61:83–108.
Wang M, Wang C, Han X. Selection of internal standards for accurate quantification of complex lipid species in biological extracts by electrospray ionization mass spectrometry-What, how and why? Mass Spectrom Rev. 2017;36:693–714.
Wang J, Wang C, Han X. Tutorial on lipidomics. Anal Chim Acta. 2019;1061:28–41.
Wilm M. Principles of electrospray ionization. Mol Cell Proteomics. 2011;10:M111.009407.
Wozny K, Lehmann WD, Wozny M, Akbulut BS, Brügger B. A method for the quantitative determination of glycerophospholipid regioisomers by UPLC-ESI-MS/MS. Anal Bioanal Chem. 2019;411:915–24.
Yang K, Han X. Lipidomics: techniques, applications, and outcomes related to biomedical sciences. Trends Biochem Sci. 2016;41:954–69.
Zhao YY, Cheng XL, Lin RC, Wei F. Lipidomics applications for disease biomarker discovery in mammal models. Biomark Med. 2015;9:153–68.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature B.V.
About this entry
Cite this entry
Engel, K.M., Popkova, Y. (2019). Electrospray Ionization Mass Spectrometry of Phospholipids. In: Wenk, M. (eds) Encyclopedia of Lipidomics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7864-1_198-1
Download citation
DOI: https://doi.org/10.1007/978-94-007-7864-1_198-1
Received:
Accepted:
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-7864-1
Online ISBN: 978-94-007-7864-1
eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences