References
Allemann RK, Scrutton NS (eds) (2009) Quantum tunnelling in enzyme-catalysed reactions. RSC biomolecular sciences. Royal Society of Chemistry, Cambridge
Cook PF (ed) (1991) Enzyme mechanism from isotope effects. CRC Press, Boca Raton
Cook PF, Cleland WW (2007) Enzyme kinetics and mechanism. Garland Science, New York/London
Fersht A (1999) Structure and mechanism in protein science: a guide to enzyme catalysis and protein folding. Freeman, New York
Klinman JP (1972) The mechanism of enzyme-catalyzed reduced nicotinamide adenine dinucleotide-dependent reductions. Substituent and isotope effects in the yeast alcohol dehydrogenase reaction. J Biol Chem 247:7977–7987
Klinman JP (1989) Quantum mechanical effects in enzyme-catalysed hydrogen transfer reactions. Trends Biochem Sci 14:368–373
Pudney CR, Hay S, Levy C, Pang J, Sutcliffe MJ, Leys D, Scrutton NS (2009) Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. J Am Chem Soc 131:17072–17073
Roston D, Kohen A (2010) Elusive transition state of alcohol dehydrogenase unveiled. Proc Natl Acad Sci U S A 107:9572–9577
Shore JD, Gutfreund H (1970) Transients in the reactions of liver alcohol dehydrogenase. Biochemistry 9:4655–4659
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Bagshaw, C.R. (2018). Kinetic Isotope Effects. In: Roberts, G., Watts, A. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35943-9_58-1
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DOI: https://doi.org/10.1007/978-3-642-35943-9_58-1
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