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Drug Delivery: Polymers in the Development of Controlled Release Systems

  • Living reference work entry
  • First Online:
Functional Polymers

Part of the book series: Polymers and Polymeric Composites: A Reference Series ((POPOC))

Abstract

This chapter comprises an overview of the basic elements that one must take into account when developing a new drug delivery system. It begins with an outline of traditional methods to deliver drugs, relating these to important considerations that must be taken into account when developing a drug delivery system, including the importance of controlling the drug concentration and location, and the properties of the device and the therapeutic. This chapter then continues by describing various types of polymeric delivery systems, including implants, hydrogels, and nanoparticles, microgels, and micelle nanomedicines. This chapter then concludes with a brief perspective on the potential of nanomedicine drug delivery systems; a much more thorough perspective can be found in a follow-up chapter “Drug Delivery: Localized and Systemic Therapeutic Strategies with Polymer Systems.”

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Abbreviations

BA:

Bioavailability

BMA:

Butyl methacrylate

CLRP:

Controlled-living free radical polymerization

CMC:

Carboxymethyl cellulose

DP A :

Hydrophobic block

DP B :

Hydrophilic block

EPR:

Enhanced permeability and retention

FDA:

US Food and Drug Administration

GI:

Gastrointestinal

HA:

Hyaluronic acid

IM:

Intramuscular

IR:

Infrared

IV:

Intravenous

MPS:

Mononuclear phagocyte system

NIPAM:

N-isopropyl acrylamide

PBA:

Phenyl boronic acid

PEG:

Poly(ethylene glycol)

PGA:

Poly(glycolic acid)

PLA:

Poly(L-lactic acid)

PLGA:

Poly(lactic acid-co-glycolic acid)

PMMA:

Poly(methyl methacrylate)

PNIPAM:

Poly(N-isopropyl acrylamide)

POEGMA:

Poly(oligoethylene glycol methacrylate)

PVA:

Polyvinyl alcohol

RGD:

Arginine-glycine-aspartic acid

SC:

Subcutaneous

SPIONs:

Superparamagnetic iron oxide nanoparticles

Tg:

Glass transition temperature

Z:

Aggregation number

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Authors and Affiliations

  1. Department of Chemical Engineering, McMaster University, Hamilton, ON, Canada

    Scott Campbell

  2. EcoSynthetix, Burlington, ON, Canada

    Niels Smeets

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  2. Niels Smeets
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  1. Minerals, King Fahd University of Petroleum a, Dhahran, Saudi Arabia

    Mohammad Abu Jafar Mazumder

  2. McMaster University, Hamilton, ON, Canada

    Heather Sheardown

  3. Minerals, King Fahd University of Petroleum a, Dhahran, Saudi Arabia

    Amir Al-Ahmed

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Campbell, S., Smeets, N. (2019). Drug Delivery: Polymers in the Development of Controlled Release Systems. In: Jafar Mazumder, M., Sheardown, H., Al-Ahmed, A. (eds) Functional Polymers. Polymers and Polymeric Composites: A Reference Series. Springer, Cham. https://doi.org/10.1007/978-3-319-92067-2_20-1

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