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Interpenetrating Polymer Network Hydrogels of Chitosan: Applications in Controlling Drug Release

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Cellulose-Based Superabsorbent Hydrogels

Part of the book series: Polymers and Polymeric Composites: A Reference Series ((POPOC))

Abstract

Chitosan is a natural polysaccharide obtained by alkaline deacetylation of chitin. It is cationic in ionic nature. Because of its biocompatibility and biodegradability, chitosan is employed as a drug carrier material in the development of various kinds of drug delivery. However, the extensive use of chitosan as a drug delivery carrier material is limited by its rapid dissolution in the acidic pH of the stomach, and this causes restrictions in controlling drug release from chitosan-based oral dosage forms. To overcome this limitation, modifications of chitosan to develop hydrogel systems are being investigated by researchers. Among these modified chitosan-based hydrogel systems, interpenetrated polymer network (IPN) hydrogels have enhanced mechanical properties at gastric pH, as well as improved control of drug release over a longer period. This chapter describes the preparations and properties, in terms of drug-releasing performance, of various chitosan-based IPN hydrogels for controlling drug release.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India

    Dilipkumar Pal

  2. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Odisha, India

    Amit Kumar Nayak

  3. Department of Pharmaceutical Sciences, Sardar Bhagwan Singh PG Institute of Biomedical Sciences and Research, Dehradun, Uttarakhand, India

    Supriyo Saha

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  1. Dilipkumar Pal
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  2. Amit Kumar Nayak
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  3. Supriyo Saha
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Correspondence to Dilipkumar Pal .

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Editors and Affiliations

  1. Department of Applied Chemistry and Chemical Engineering, University of Rajshahi, Rajshahi, Bangladesh

    Md. Ibrahim H. Mondal

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Pal, D., Nayak, A.K., Saha, S. (2019). Interpenetrating Polymer Network Hydrogels of Chitosan: Applications in Controlling Drug Release. In: Mondal, M. (eds) Cellulose-Based Superabsorbent Hydrogels. Polymers and Polymeric Composites: A Reference Series. Springer, Cham. https://doi.org/10.1007/978-3-319-77830-3_57

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