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Prick and Intracutaneous Testing and IgE Testing

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Kanerva’s Occupational Dermatology

Abstract

Immediate-type allergies are frequent in specific occupational environments.

Most important is to consider the possibility of occupational factors in allergic diseases.

Depending on the substance, immunological and nonimmunological mechanisms may be relevant for symptom elicitation.

According to European Directive 2001/83/EC in vivo test allergens are medicinal products, whereas test allergens for in vitro use are medical devices following respective regulations. Standardized test preparations for in vivo and/or in vitro testing for specific IgE to occupational allergen sources are rare. False-negative as well as false-positive test reactions may occur with current test methods for detection of specific IgE to occupational allergen sources. Compared to ubiquitous inhalant allergens (cut-off ≥ 3.00 mm wheal diameter), for occupational allergens, a different cut-off (wheal diameter ≥ 1.5 mm) applies.

Skin prick testing, intracutaneous testing and in vitro investigation of specific IgE constitute one component in a stepwise assessment for diagnosis of allergen-induced occupational diseases.

High- and low-molecular-weight allergens have to be considered as occupational allergen sources in specific work environments.

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Authors and Affiliations

  1. Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany

    Vera Mahler

  2. Medical Faculty, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany

    Vera Mahler

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  1. Vera Mahler
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Correspondence to Vera Mahler .

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Editors and Affiliations

  1. Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany

    Swen Malte John

  2. National Allergy Research Centre, Department of Dermatology and Allergy, Herlev-Gentofte University Hospital, Hellerup, Hellerup, Denmark

    Jeanne Duus Johansen

  3. Department of Dermatology and Allergology, VU University Medical Center, Amsterdam, The Netherlands

    Thomas Rustemeyer

  4. Department of Dermatology, University Hospital Jena, Jena, Germany

    Peter Elsner

  5. Department of Dermatology, University of California, San Francisco, CA, USA

    Howard I. Maibach

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Mahler, V. (2020). Prick and Intracutaneous Testing and IgE Testing. In: John, S., Johansen, J., Rustemeyer, T., Elsner, P., Maibach, H. (eds) Kanerva’s Occupational Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-68617-2_84

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  • DOI: https://doi.org/10.1007/978-3-319-68617-2_84

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