Abstract
Occupational and environmental acne is an acneiform disorder, resulting from various chemical exposures and from a variety of environmental, physical, and mechanical factors, usually encountered in the workplace but occasionally seen in nonoccupational settings. Occupational and environmental acne comprises oil acne, coal-tar and pitch acne, acne cosmetica, acne aestivalis (from sun), acne mechanica, tropical acne, drug-induced acne, and chloracne. Chloracne, although rare, is a sensitive indicator of chemical exposure to certain polyaromatic halogenated hydrocarbons and is often associated with systemic involvement that should be recognized by physicians treating occupational skin disease. Diagnosis of occupational and environmental acne requires a detailed medical history including possible physical, chemical, and environmental causative agents, a compatible clinical and histologic picture and distribution usually beyond the typical locations of acne vulgaris. Putative chloracnegens should be identified by environmental measurements and also may be assessed in serum and various tissues by direct chemical analysis or biological assay. Management of occupational and environmental acne involves removing or limiting exposure to the putative chemical agent, wearing chemical protective equipment, worker education, and topical and systemic pharmaceutical therapy as indicated.
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References
Abel J, Haarmann-Stemmann T (2010) An introduction to the molecular basics of aryl hydrocarbon receptor biology. Biol Chem 391:1235–1248
Adams BB, Chetty VB, Mutasim DF (2000) Periorbital comedones and their relationship to pitch tar: a cross-sectional analysis and a review of the literature. J Am Acad Dermatol 42(4):624–627
Agency for Toxic Substances and Disease Registry (1993) Dioxin toxicity. Am Fam Physician 47:855–861
Ancona AA (1986) Occupational acne. Occup Med 1(2):229–243
Baccarelli A, Pesatori AC, Consonni D et al (2005) Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident. Br J Dermatol 152(3):459–465
Barouti N, Fontao L, Pardo B et al (2009) AhR pathway as a novel pharmacological target for wound healing. J Invest Dermatol 129:S80
Bartolini R (1989) Acne. A summary of the occupational health concern. Canadian Centre for Occupational Health and Safety, Hamilton. Report No. F89-1E:I7
Bleiberg I, Wallen M, Brodken R et al (1964) Industrial acquired porphyria. Arch Dermatol 89:793–797
Bock KW, Kohle C (2009) The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver. Biol Chem 390:1225–1235
Bodner KM, Collins JJ, Bloemen LJ et al (2003) Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Occup Environ Med 60(9):672–675
Brun P, Baran R (1984) A special type of mechanical acne: fiddler’s neck dermatitis. Ann Dermatol Venereol 111(3):241–245
Burns CJ, Garabrant D, Albers JW et al (2006) Chlorpyrifos exposure and biological monitoring among manufacturing workers. Occup Environ Med 63:218–220
Caputo R, Monti M, Ermacora E et al (1988) Cutaneous manifestations of tetrachlorodibenzo-p-dioxin in children and adolescents. J Am Acad Dermatol 19:812–819
Chen LC, Berberian I, Koch B et al (1992) Polychlorinated and polybrominated biphenyl congeners and retinoid levels in rat tissues: structure-activity relationships. Toxicol Appl Pharmacol 114:47–55
Chlebus E, Chlebus M (2017) Factors affecting the course and severity of adult acne. Observational cohort study. J Dermatolog Treat 10:1–21
Clemens MW, Kochuba AL, Carter ME et al (2014) Association between Agent Orange exposure and nonmelanotic invasive skin cancer: a pilot study. Plast Reconstr Surg 133(2):432–437
Coenraads PI, Brouwer A, Olie K, Tang N (1994) Chloracne. Some recent issues. Dermatol Clin 12:569–576
Cohen PR (2015) Sorafenib-associated facial acneiform eruption. Dermatol Ther (Heidelb) 5(1):77–86
Cole GW, Stone O, Gates D, Culver D (1986) Chloracne from pentachlorophenol – preserved wood. Contact Dermatitis 15:164–168
Cole P, Trichopoulos D, Pastides H et al (2003) Dioxin and cancer: a critical review. Regul Toxicol Pharmacol 38(3):378–388
Crow KD (1981) Chloracne and its potential clinical implications. Clin Exp Dermatol 6:243–257
Crow KD, Puhvel MS (1991) Chloracne (halogen acne). In: Manulli FN, Maibach HI (eds) Dermatoxicology. Hemisphere, New York, pp 647–667
Cunliffe WJ, Williams M, Edwards JC et al (1975) An explanation for chloracne-an industrial hazard. Acta Derm Venereol (Stockh) 55:211–214
De Gálvez Aranda MV, Sánchez PS, Alonso Corral MJ et al (2001) Acneiform eruption caused by amineptine. A case report and review of the literature. J Eur Acad Dermatol Venereol 15(4):337–339
de Waard PW, Peijnenburg AA, Baykus H et al (2008) A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine. Chem Biol Interact 176:19–29
Demirci U, Coskun U, Erdem O, Ozturk B, Yilmaz IB, Benekli M, Buyukberber S (2011) Acne rosacea associated imatinib mesylate in a gastrointestinal stromal tumor patient. J Oncol Pharm Pract 17(3):285–287
den Besten C, Bennik MHJ, Bruggeman I et al (1993) The role of oxidative metabolism in hexachlorobenzene induced porphyria and thyroid hormone homeostasis: a comparison with pentachlorobenzene in a 13-week feeding study. Toxicol Appl Pharmacol 119:181–194
Draelos ZD, DiNardo JC (2006) A re-evaluation of the comedogenicity concept. J Am Acad Dermatol 54(3):507–512
Fabbrocini G, Kaya G, Caseiro Silverio P, De Vita V, Kaya A, Fontao F, Sorg O, Saurat JH (2015) Aryl Hydrocarbon Receptor Activation in Acne Vulgaris Skin: A Case Series from the Region of Naples, Italy. Dermatology 231(4):334–8
Fernández-Crehuet P, Ruiz-Villaverde R (2015) Acneiform eruption as a probable paradoxical reaction to adalimumab. Int J Dermatol 54(8):e306–e308
Fitzgerald EF, Weinstein AL, Youngblood LG et al (1989) Health effects three years after potential exposure to the toxic contaminants of an electrical transformer fire. Arch Environ Health 44:214–221
Formicone F, Fargnoli MC, Pisani F et al (2005) Cutaneous manifestations in Italian kidney transplant recipients. Transplant Proc 37:2527–2528
Frumkin H (2003) Agent Orange and cancer: an overview for clinicians. CA Cancer J Clin 53(4):245–55
Furue M, Takahara M, Nakahara T et al (2014) Role of AhR/ARNT system in skin homeostasis. Arch Dermatol Res 306:769–779
Gawkrodger DJ (1991) Chloracne: causation, diagnosis and treatment. J Dermatol Treat 2:73–76
Gawkrodger DJ, Harris G, Bojar RA (2009) Chloracne in seven organic chemists exposed to novel polycyclic halogenated chemical compounds (triazoloquinoxalines). Br J Dermatol 161(4):939–943
Geusau A, Tschachler E, Meixner M et al (1999) Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Lancet 354:1266–1269
Geusau A, Jurecka W, Nahavandi H et al (2000) Punctate keratoderma-like lesions on the palms and soles in a patient with chloracne: a new clinical manifestation of dioxin intoxication? Br J Dermatol 143(5):1067–1071
Gladen BC, Taylor JS, Wu YC, Ragan NB, Rogan WJ, Hsu CC (1990) Dermatologic findings in children exposed transplacentally to heat-degraded polychlorinated biphenyls in Taiwan. Br J Dermatol 122:799–808
Gracia-Cazaña T, Pastushenko I, Concellón MA, Grasa-Jordán MP (2014) A comedonal acneiform eruption following dovitinib therapy. Clin Exp Dermatol 39(7):842–843
Guyot E, Chevallier A, Barouki R, Coumoul X (2013) The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications. Drug Discov Today 18:479–486
Hahn ME (2002) Aryl hydrocarbon receptors: diversity and evolution. Chem Biol Interact 141:131–160
Hambrick GS (1957) The effects of substituted napthalenes on the pilosebacious apparatus of rabbit and man. J Invest Dermatol 28:29–103
Hankinson O (2009) Repression of aryl hydrocarbon receptor transcriptional activity by epidermal growth factor. Mol Interv 9(3):116–118
Hardell L, Sandstrom A (1979) Case-control study: soft tissue sarcoma and exposure to phenoxy-acetic acids or chlorophenols. Br J Cancer 39:711–717
Hayes JD, Dinkova-Kostova AT, McMahon M (2009) Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin. Toxicol Sci 111:199–201
Herxheimer K (1899) Ueber chlorakne. Munch Med Wochenschr 46:278
Hjorth N, Sjolin KE, Sylvest B et al (1972) Acne aestivalis: Mallorca acne. Acta Derm Venereol 52:61–63
Hryhorczuk DO, Wallace WH, Persky V et al (1998) A morbidity study of former pentachlorophenol-production workers. Environ Health Perspect 106(7):401–408
Hsu MM, Mak CP, Hsu CC (1995) Follow up of skin manifestations in Yu-Cheng children. Br J Dermatol 132(3):427–432
IARC (1997) IARC monograph on the evaluation of carcinogenic risks to humans: polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans, vol 69. IARC, Lyon
Ikaraoha CI, Mbadiwe NC, Anyanwu CJ, Odekhian J, Nwadike CN, Amah H (2017) The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population. Biol Trace Elem Res 176(2):251–257
Jalalat SZ, Cohen PR (2013) Gefitinib-associated vitiligo: report in a man with parotid squamous cell carcinoma and review of drug-induced hypopigmentation. Dermatol Online J 19(10):20020
Jirasek L, Kalensky J, Kubec K (1973) Acne chlorina and porphyria cutanea tarda during the manufacturing of herbicides Part I. Cesk Dermatol 48:306–317
Ju Q, Yu Q, Song N et al (2011) Expression and significance of aryl hydrocarbon receptor on human epidermis, hair follicle, and sebaceous gland. Chin J Dermatol 44:761–764
Kansal NK, Sharma M (2013) Acneiform eruption and pruritus in a patient with quetiapine therapy. Skinmed 11(5):317–318
Kashat M, Caretti K, Kado J (2014) Etanercept-induced cystic acne. Cutis 94(1):31–32
Kersevovich J, Langenberg A, Odom RB et al (1992) Dowling-Degos’ disease mimicking chloracne. J Am Acad Dermatol 27:345–348
Khanna N, Gupta SD (1999) Acneiform eruptions after facial beauty treatment. Int J Dermatol 38(3):196–199
Khanna S, Chirinos RE, Venna S (2012) Escitalopram oxalate (Lexapro)-induced acneiform eruption. J Am Acad Dermatol 67(6):e261–e263
Kligman AM, Mills OH (1972) Acne cosmetica. Arch Dermatol 106:843–850
Knox JM, Dinehart SM et al (1986) Acquired perforating disease in oil field workers. J Am Acad Dermatol 14:605–611
Köhle C, Bock KW (2007) Coordinate regulation of phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol 73:1853–1862
Kokelj F (1992) Occupational acne. Clin Dermatol 10:213–217
Litt JZ (1974) McDonald’s acne. Arch Dermatol 110:956
Longnecker MP, Rogan WJ, Lucier G (1997) The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBs (polychlorinated biphenyls) and overview of organochlorines in public health. Annu Rev Public Health 18:211–244
Martín JM, Jordá E, Monteagudo C, Alonso V, García L, Villalón G (2006) Follicular acneiform eruption induced by imatinib. J Eur Acad Dermatol Venereol 20(10):1368–1370
Masuda Y (2001) Fate of PCDF/PCB congeners and change of clinical symptoms in patients with Yusho PCB poisoning for 30 years. Chemosphere 43(4–7):925–930
Mathias CGT (1994) Occupational dermatoses. In: Zenz C, Dickerson OB, Horvath EP (eds) Occupational medicine, 3rd edn. Mosby, St. Louis, pp 93–131
McDonough AI, Gawkrodger DJ, Walker AE (1993) Chloracne study of an outbreak with new clinical observations. Clin Exp Dermatol 18:523–525
Michot C, Guillot B, Dereure O (2010) Lenalidomide-induced acute acneiform folliculitis of the head and neck: not only the anti-EGF receptor agents. Dermatology 220(1):49–50
Mills OH, Kligman A (1975) Acne mechanica. Arch Dermatol 111:481–483
Molina-Ruiz AM, Domine M, Requena L (2013) Acute and severe acne in a patient treated with bevacizumab. Int J Dermatol 52(4):486–490
Mukerjee D (1998) Health impact of polychlorinated dibenzo-p-dioxins: a critical review. J Air Waste Manag Assoc 48:157–165
Nguyen SH, Dang TP, Maibach HI (2007) Comedogenicity in rabbit: some cosmetic ingredients/vehicles. Cutan Ocul Toxicol 26(4):287–292
Niu YM, Hao FT, Xia YJ (2014) Sodium 3,5,6-trichloropyridin-2-ol poisoning: report of four cases. Toxicol Ind Health 30(5):475–479
O’Malley MS, Carpenter AV, Sweeney MH, Fingerhut MA et al (1990) Chloracne associated with employment in the production of pentachlorophenol. Am J Ind Med 17:411–421
Omohundro C, Taylor JS (1998) Occupational acne. In: English JSC (ed) A colour handbook of occupational dermatology. Manson, London, pp 121–134
Osio A, Mateus C, Soria JC, Massard C, Malka D, Boige V, Besse B, Robert C (2009) Cutaneous side-effects in patients on long-term treatment with epidermal growth factor receptor inhibitors. Br J Dermatol 161(3):515–521
Panteleyev AA, Bickers DR (2006) Dioxin-induced chloracne – reconstructing the cellular and molecular mechanisms of a classic environmental disease. Exp Dermatol 15:705–730
Panteleyev AA, Thiel R, Wanner R, Zhang J, Roumak VS, Paus R, Neubert D, Henz BM, Rosenbach T (1997) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCCD) affects keratin 1 and keratin 17 gene expression and differentially induces keratinization in hairless mouse skin. J Invest Dermatol 108(3):330–5
Passarini B, Infusino SD, Kasapi E (2010) Chloracne: still cause for concern. Dermatology 221:63–70
Patterson AT, Tian FT, Elston DM et al (2015) Occluded cigarette smoke exposure causing localized chloracne-like comedones. Dermatology 231(4):322–325
Pelclova D, Urban P, Preiss J et al (2006) Adverse health effects in humans exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rev Environ Health 21(2):119–138
Pesatori AC, Consonni D, Bachetti S et al (2003) Short- and long-term morbidity and mortality in the population exposed to dioxin after the “Seveso accident”. Ind Health 41(3):127–138
Pesatori AC, Consonni D, Rubagotti M et al (2009) Cancer incidence in the population exposed to dioxin after the “Seveso accident”: twenty years of follow-up. Environ Health 8:39
Petukhova TA, Novoa RA, Honda K et al (2013) Acneiform eruptions associated with vemurafenib. J Am Acad Dermatol 68(3):e97–e99
Plewig G, Jansen T (1998) Acneiform dermatoses. Dermatology 196:102–107
Plewig G, Kligman AM (1993) Acne and rosacea, 2nd edn. Springer, Berlin, pp 360–429
Pocchiari F, Silano V, Zampieri A (1979) Human health effects from accidental release of tetrachlorodibenzo-p-dioxin (TCDD) at Seveso, Italy. Ann N Y Acad Sci 320:311–320
Poland A, Glover E, Kende AS (1976) Stereo-specific high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. J Biol Chem 251:4936–4946
Poskitt LB, Duffill MB, Rademaker M (1994) Chloracne, palmoplantar keratoderma and localized scleroderma in a weed sprayer. Clin Exp Dermatol 19:264–267
Proudfoot AT (2003) Pentachlorophenol poisoning. Toxicol Rev 22(1):3–11
Rodriguez-Pichardo A, Camacho F, Rappe C, Hansson M, Smith AG, Greig IB (1991) Chloracne caused by ingestion of olive oil contaminated with PCDDs and PCDFs. Hum Exp Toxicol 10:311–322
Rogan WJ, Gladen BC, Hung K-L, Koong S-L, Shih L-Y, Taylor JS (1988) Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 241:334–336
Ryan JJ, Schecter A (2000) Exposure of Russian phenoxy herbicide producers to dioxins. J Occup Environ Med 42(9):861–870
Saurat JH, Sorg O (2010) Chloracne, a misnomer and its implications. Dermatology 221:23–26
Saurat JH, Kaya G, Saxer-Sekulic N et al (2012) The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko. Toxicol Sci 125:310–317
Scerri L, Zaki I, Millard LG (1995) Severe halogen acne due to a trifluoromethylpyrazole derivative and its resistance to isotretinoin. Br J Dermatol 132:144–148
Schäfer M, Willrodt AH, Kurinna S et al (2014) Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. EMBO Mol Med 6(4):442–457
Seneschal J, Kubica E, Boursault L et al (2012) Exogenous inflammatory acne due to combined application of cosmetic and facial rubbing. Dermatology 224(3):221–223
Sheu J, Hawryluk EB, Litsas G et al (2015) Papulopustular acneiform eruptions resulting from trastuzumab, a HER2 inhibitor. Clin Breast Cancer 15(1):e77–e81
Sinha S, Udupa S, Bhandary RP et al (2014) Sertraline-induced acneiform eruption. J Neuropsychiatry Clin Neurosci 26(2):E56–E57
Sorg O (2014) AhR signalling and dioxin toxicity. Toxicol Lett 230(2):225–233
Sorg O, Zennegg M, Schmid P et al (2009) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites. Lancet 374:1179–1185
Sperling L (1994) Skin disease associated with excessive heat, humidity, and sunlight. In: Zajtchuk R (ed) Textbook of military medicine, part III. Sergent General, Department of the Army, Washington, DC, pp 44–45
Sterling JB, Hanke CW (2005) Dioxin toxicity and chloracne in the Ukraine. J Drugs Dermatol 4(2):148–150
Strik JJ (1979) Porphyrins in urine as an indicator of exposure to chlorinated hydrocarbons. Ann N Y Acad Sci 320:308–310
Suskind RR (1985) Chloracne, “the hallmark of dioxin intoxication”. Scand J Work Environ Health 11(3 Spec No):165–171
Sutter CH, Yin H, Li Y et al (2009) EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes. Proc Natl Acad Sci U S A 106(11):4266–4271
Sweeney MH, Mocarelli P (2000) Human health effects after exposure to 2,3,7,8-TCDD. Food Addit Contam 17(4):303–316
Tan NS, Wahli W (2014) The emerging role of Nrf2 in dermatotoxicology. EMBO Mol Med 6(4):431–3
Taylor JS (1974) Chloracne, a continuing problem. Cutis 13:585–591
Taylor JS (1979) Envionmental chloracne: update and overview. Ann N Y Acad Sci 320:295–307
Taylor JS (1986) Occupational dermatoses. In: Conn HF (ed) Current therapy. WB Saunders, Philadelphia, pp 686–688
Taylor JS (1987) Pilosebaceous unit. In: Maibach HI (ed) Occupational and industrial dermatology. Year Book Medical Publishers, Chicago, pp 105–120
Taylor JS, Lloyd KM (1982) Chloracne from 3.3′,4,4′-tetrachloroazoxybenzene and 3.3′,4,4′-tetrachloroazobenzene: update and review. In: Hutzinger O (ed) Chlorinated dioxins and related compounds. Pergamon, Oxford, pp 535–544
Taylor JS, Wuthrich RC, Lloyd KM, Poland A (1977) Chloracne from manufacture of a new herbicide. Arch Dermatol 113:616–619
Thomke F, Jung D, Besser R et al (1999) Increased risk of sensory neuropathy in workers with chloracne after exposure to 2,3,7,8-polychlorinated dioxins and furans. Acta Neurol Scand 100(1):1–5
Tindall JP (1985) Chloracne and chloracnegens. J Am Acad Dermatol 13:539–558
Tuomisto J, Tuomisto JT (2012) Is the fear of dioxin cancer more harmful than dioxin? Toxicol Lett 210:338–344
Upreti RK, Das M, Shanker R (1989) Dermal exposure to kerosene. Vet Hum Toxicol 31:16–20
Uribe P, Anforth RM, Kefford RF, Fernandez-Peñas P (2014) Acneiform eruption in a patient with metastatic melanoma after ceasing combination dabrafenib/trametinib therapy. Melanoma Res 24(5):501–503
Vazquez ER, Macias PC, Tirado IG, Solana CG, Casanova A, Moncada IF (1996) Chloracne in the 1990s. Int J Dermatol 35:643–645
Veterans Administration Chloracne Task Force (1984) Guidelines for the diagnosis of chloracne. U.S. Veterans Administration, Washington, DC
Veysey EC, George S (2005) Actinic folliculitis. Clin Exp Dermatol 30(6):659–661
Wu N, Hao F, Yu X (2012) Peripheral nerve and skin damage associated with working in a STCP factory: report of four cases. Clin Toxicol 50(6):514–517
Yip J, Peppall L, Gawkrodger DJ, Cunliff WJ (1993) Light cautery and EMLA in the treatment of chloracne lesions. Br J Dermatol 128:313–316
Zaenglein AL, Thiboutot DM (2008) Acne vulgaris. In: Bolognia JL, Jorizzo JL, Rapini RP (eds) Dermatology, 2nd edn. Mosby, London, pp 495–508
Zugerman C (1990) Chloracne, chloracnegenesis, and other forms of environmental acne. In: Adams RM (ed) Adams occupational skin disease, 2nd edn. WB Saunders, Philadelphia, pp 127–135
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Wattanakrai, P., Taylor, J.S. (2020). Occupational and Environmental Acne. In: John, S., Johansen, J., Rustemeyer, T., Elsner, P., Maibach, H. (eds) Kanerva’s Occupational Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-68617-2_31
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